Evidence map›Paper›PMID 42427992›Full record

ArticleFrontiers in digital health2026

K-anonymity decay in multi-turn clinical large language model conversations.

James Weatherhead, Azra Hasan, Jake Weatherhead, George Golovko, Bradley Grant, Juan David Garcia, Hugo Sebastian Certuche, Reuben Peter Powell, Jose Marri Abril, Peter McCaffrey

Abstract read
In one paragraph

Article in Frontiers in digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James WeatherheadGraduate School of Biomedical Sciences, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Azra HasanDepartment of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Jake WeatherheadDepartment of Computer Science, University of Pretoria, Pretoria, South Africa.
George GolovkoDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Bradley GrantDepartment of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Juan David GarciaDepartment of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Hugo Sebastian CertucheGraduate School of Biomedical Sciences, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Reuben Peter PowellDepartment of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Jose Marri AbrilTransplant Division, Department of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.
Peter McCaffreyDepartment of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per-prompt de-identification, a commonly adopted practice for protecting patient privacy in clinical artificial intelligence (AI) conversations, may be insufficient to bound re-identification risk when the same patient is discussed across multiple conversational turns. Under the Health Insurance Portability and Accountability Act (HIPAA) Safe Harbor method, eighteen specified identifier categories must be removed from each disclosure independently, but this approach does not assess cumulative re-identification risk: successive turns reveal additional quasi-identifiers that progressively narrow the set of matching records, eroding the privacy protection that any single turn appeared to provide. We quantified this vulnerability by simulating progressive quasi-identifier disclosure, modeled on clinical case presentations, against a synthetic electronic health record cohort. Under progressive disclosure, 79.9% of simulated patients fell below the small-cell threshold (

Indexed as

clinical decision supportde-identificationHIPAAk-anonymitylarge language modelsre-identificationshadow AIsynthetic data

Identifiers

PMID42427992
PMCPMC13346167

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.