Evidence map›Paper›PMID 42427965›Full record

ArticleExtracellular vesicle2026

Advancements in extracellular vesicle research.

Bingrui Li, Valerie S Kalluri, Alissa M Weaver, Irene Bertolini, John J S Cadwell, Ameya Chaudhari, Saumya Das, Zankruti Dave, Jose Francis-Oliveira, Samir El Andaloussi and 55 more

Abstract read
In one paragraph

Article in Extracellular vesicle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

65 authors.

Bingrui LiDepartment of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Valerie S KalluriDepartment of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-8514-8551
Alissa M WeaverDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, USA.ORCID 0000-0002-4096-8636
Irene BertoliniMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID 0000-0001-5824-6802
John J S CadwellFiberCell Systems Inc., New Market, Md, USA.
Ameya ChaudhariDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0003-0456-5677
Saumya DasCardiovascular Research Center, Heart and Vascular Institute, Mass General Brigham, Boston, MA, 02114, USA.ORCID 0000-0002-4521-4606
Zankruti DaveDivision for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Jose Francis-OliveiraUniversity of Alabama at Birmingham, Department of Psychiatry and Behavioral Neurobiology, Birmingham, AL, USA.ORCID 0000-0002-1539-4618
Samir El AndaloussiDivision for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Brian P EliceiriDepartment of Surgery, University of California San Diego, La Jolla, CA, USA.
Susanne GabrielssonDivision of Immunology and Respiratory Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden.ORCID 0000-0003-1771-1346
Marta Garcia-ContrerasCardiovascular Research Center, Heart and Vascular Institute, Mass General Brigham, Boston, MA, 02114, USA.
Bernd GiebelInstitute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Germany.ORCID 0000-0003-2446-948X
Tal GilboaEverest Biolabs, Waltham, MA, 02451, USA.
André GörgensDivision for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9198-0857
Steve GouldDepartment of Cell Biology, Johns Hopkins University School of Medicine, USA.ORCID 0000-0002-4231-998X
Steven J GrecoPranaX Corporation, Houston, TX, USA.
Asa B GustafssonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Mei HeDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Mengying HuDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.
Tony Y HuCenter for Intelligent Molecular Diagnostics, Department of Biochemistry and Molecular Biology, School of Medicine, Tulane University, USA.
Keisuke ItoRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Hailing JinDepartment of Microbiology & Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, 92521, USA.
Jennifer C JonesNational Cancer Institute, Bethesda, MD, 20892, USA.
Ananth Kumar KammalaDepartment of OBGYN, Division of Basic Science and Translational Research, The University of Texas Medical Branch at Galveston, TX, USA.
Lucia R LanguinoDepartment of Pharmacology, Physiology and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Louise C LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-2095-7534
Xiuming LiangDivision for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Hongyan LiaoCenter for Intelligent Molecular Diagnostics, Department of Biochemistry and Molecular Biology, School of Medicine, Tulane University, USA.
Fei LiuDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Mengrui LiuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Jason LoweryBeckman Coulter Life Sciences, USA.
Devika Soundara ManickamDuquesne University, 600 Forbes Avenue, Pittsburgh, PA, 15282, USA.
Kathleen M McAndrewsDepartment of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ramkumar MenonDivision of Basic Science and Translational Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch, TX, USA.
Aleksandar MilosavljevicDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Takahisa NakamuraDivision of Endocrinology, Cincinnati Children's Hospital Medical Center, OH, USA.
Martin NgDepartment of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA, 94121, USA.
Juliane NguyenDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
John NolanScintillon Institute, San Diego, CA, USA.
Heather PuaDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, USA.ORCID 0000-0002-9271-2608
Ferdinando PucciDepartment of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-1300-9931
Robert L RaffaiDepartment of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA, 94121, USA.
Shikha RaniTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, QLD, 4006, Australia.ORCID 0000-0002-9574-9406
Vijay A RathinamDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, 06030, USA.
Susmita SahooCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ana Isabel Salazar PuertaDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Najla Adel SalehInstitute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA.
Carlos SalomonTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston, QLD, 4006, Australia.
Michail SpanosCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.
Loïc SteinerDivision of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Yong TaoDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Oscar P B WiklanderKarolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.
Junjie XiaoCardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Science, Shanghai University, Shanghai, 200444, China.
Yanlian YangNational Center for Nanoscience and Technology, Beijing, 100190, China.
Wei YingDivision of Endocrinology and Metabolism, Department of Medicine, University of California, La Jolla, San Diego, CA, USA.
John YuInstitution of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linko, Taiwan.
Li YuState Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.
Janos ZempleniDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0001-5492-4661
Mingli ZhuDepartment of Ophthalmology, University of California San Francisco, CA, 94143, USA.ORCID 0009-0002-0137-4365
Zheng ZhuangEXODUS Bio, USA.
Antje Maria ZicklerDivision for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5001-6586
Ke ChengDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Raghu KalluriDepartment of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-2190-547X

Funding

Direct quantitation of the circulating Mtb-peptidome for pediatric TB managementR01HD090927 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon, Charles DeBeaux Mitchell · 2017 to 2026
$4.5M
Digital Nanoplasmonic Quantification of Tumor-derived Extracellular Vesicles in Plasma MicrosamplesU01CA252965 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y., LU, HUA · 2020 to 2024
$3.0M
Quantification of brain-derived extracellular vesicle microRNAs in blood by a liposome-mediated CRISPR assay for traumatic brain injury detectionR21NS130542 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y. · 2022 to 2022
$437k
BLRD VA I01 BX003928BLRD VA IK6 BX005692NCI NIH HHS U01 CA252965NICHD NIH HHS R01 HD090927NINDS NIH HHS R21 NS130542
6 · The paper itself

Abstract

The AAEV (American Association of Extracellular Vesicles) Annual Meeting at the John P. McGovern Commons in Houston, TX convened over 300 leading researchers, clinicians, and industry experts from around the world to advance the rapidly evolving field of extracellular vesicle (EV) science. EVs, nanoscale lipid-bound particles released by all prokaryotic and eukaryotic cells, have emerged as crucial mediators of intercellular communication, trans- porting proteins, nucleic acids, and lipids that influence a wide spectrum of physiological and pathological processes. Their involvement in immune modulation, tissue regeneration, cancer progression, metabolic regulation, and other complex biological functions positions EVs as promising diagnostic biomarkers and therapeutic delivery agents in precision medicine and personalized healthcare. However, significant challenges persist, including the heterogeneity of EV populations, complexities in isolation and purification, and the pressing need for standardized characterization protocols. The 2024 AAEV's annual gathering provided a pivotal forum for exchanging insights and cultivating collaborations. The meeting featured keynote addresses delved into the intricate heterogeneity, biogenesis pathways, and immu- nomodulatory capabilities of EVs, as well as their contributions to disease progression. Subsequent sessions covered a broad range of topics, showcasing cutting-edge technologies for EV isolation and characterization, revealing novel mechanisms by which EVs modulate immune responses and disease states, and presenting innovative EV engineering approaches for delivering therapeutics. Industry presentations complemented academic discussions by introducing scalable EV production systems, automated isolation methods, specialized analytical tools, and strategies to navigate regulatory pathways. Alongside these presentations, the association supports dissemination of the latest discoveries and methodologies through its flagship publication, Extracellular Vesicle (EV). Collectively, the insights shared at the AAEV Annual Meeting underscored the remarkable progress in understanding EV complexity, refining isolation and analysis techniques and translating fundamental discoveries into clinically actionable solutions. Speakers highlighted advanced isolation platforms, refined bioengineering methods, and efforts to integrate EV-based diagnostics and therapeutics into existing clinical frameworks. As the field matures, the forward momentum reflects a transition from theoretical potential to tangible applications. By fostering global collaboration, strengthening ties between academia and industry, and providing platforms like the EV journal, for ongoing dialogue, the EV community is well-positioned to surmount current challenges and accelerate the integration of EV-based approaches into mainstream healthcare.

Identifiers

PMID42427965
PMCPMC13348814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.