ArticleFrontiers in pediatrics2026
Deep brain stimulation for pediatric dystonia under general anesthesia with endotracheal intubation: case series in a tertiary hospital.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Deep brain stimulation (DBS) has increasingly become an accepted therapy for pediatric patients with medically refractory dystonia. Most pediatric dystonia patients are unable to tolerate the DBS procedure under local anesthesia or awake anesthesia. Therefore, general anesthesia is a potentially feasible choice. However, the negative impacts of general anesthetics may impair the quality of intraoperative microelectrode recording (MER). Additionally, pediatric dystonia patients frequently present with comorbidities including difficult airway, cardiovascular dysfunction, respiratory impairment, and metabolic disorders, which collectively posing challenges to perioperative management. Methods: In this study, we retrospectively reviewed the anesthetic managements for 32 pediatric dystonia patients who received DBS surgery in our center, and analyzed the safety profile and adverse effects. Results and Conclusions: We found that general anesthesia with endotracheal intubation might be a feasible anesthetic regimen for this pediatric dystonia patient population. Challenges regarding the anesthetic management of these patients mainly come from the potential impacts of general anesthetics on MER quality, patients' fragility secondary to severe dystonia, and the pathophysiological disorders associated with comorbid conditions. Therefore, meticulous perioperative monitors are required and special concerns should be paid to preventing perioperative complications caused by anesthetic procedure and some rare but serious hereditary metabolic disorders.
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