Evidence map›Paper›PMID 42427879›Full record

ArticleResearch square2026

Timesynth: A Temporal Fidelity Framework for Health Signal Digital Twins.

Md Rakibul Haque, Shireen Elhabian, Warren Woodrich Pettine

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Md Rakibul HaqueScientific Computing and Imaging Institute, University of Utah, Salt Lake City, 84112, UT, USA.
Shireen ElhabianScientific Computing and Imaging Institute, University of Utah, Salt Lake City, 84112, UT, USA.
Warren Woodrich PettineDepartment of Psychiatry, University of Utah, Salt Lake City, UT, USA.

Funding

Prediction of suicide death using EHR and polygenic risk scoresR01MH123489 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI COON, HILARY · 2020 to 2025
$4.2M
Genetic risk discovery using WGS from a population-based resource of 10,000 suicide deaths with DNAR01MH122412 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Hilary Coon · 2020 to 2026
$2.7M
NIA NIH HHS L70 AG096751NIMH NIH HHS R01 MH122412NIMH NIH HHS R01 MH123489
6 · The paper itself

Abstract

Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost. We show that this blind spot misranks models: across 11 architectures, models with comparable pointwise error diverge by up to

Indexed as

Digital TwinForecasting ModelsPhysiological SignalsState Change

Identifiers

PMID42427879
PMCPMC13345539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.