ArticleResearch square2026
GlyGen: a knowledgebase linking glycan data with protein and gene data to reveal novel biological connections.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Glycans influence protein structure and function, modulate tissue development, regulate organ function, drive pathogen interactions, control inflammation and immunity, and impact most disease processes. However, glycan and glycosylation data are frequently difficult to access, existing across heterogeneous resources, with inconsistent representation and limited linkage to the genes, proteins, and protein sites that define their biological context. This fragmentation limits integration with genomics, proteomics, and other omics data, and constrains the discovery of glycan-mediated relationships. GlyGen is a knowledgebase designed to harmonize and integrate glycan, protein, and glycosylation data within a unified, glycosylation-centric data model. The model currently captures 58,841 glycans, 243,702 proteins, and 183,573 glycosylation sites, and extends to motifs, diseases, biomarkers, as well as germline and somatic sequence variations. Data are collected from public resources and literature, standardized using identifiers such as UniProt and GlyTouCan accessions, and integrated through ontology-driven workflows with evidence tracking and attribution. GlyGen supports free access via a web portal, APIs, downloads, and semantic web technologies. The current release (www.glygen.org) integrates diverse datasets across 16 organisms with extensive cross-references and provides an interoperable framework for advancing the integration of glycoscience into the broader biomedical data ecosystem.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.