Evidence map›Paper›PMID 42427866›Full record

ArticleResearch square2026

Single-cell genomics links targeted functional manipulations to efficacy-associated chromatin signatures in CAR T cells.

Kole R DeGolier, Stephanie DeVoe, Marwan A Abushawish, Angela Prete, Terry J Fry, James P Scott-Browne

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kole R DeGolierDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA, 80206.
Stephanie DeVoeDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA, 80206.ORCID 0000-0003-2626-8366
Marwan A AbushawishDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA, 80206.
Angela PreteDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA, 80206.
Terry J FryDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA, 80045.
James P Scott-BrowneDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA, 80206.

Funding

Transcriptional Control of T Cell FunctionR01AI151021 · NIAID · NATIONAL JEWISH HEALTH · PI SCOTT-BROWNE, JAMES · 2021 to 2025
$2.0M
NIAID NIH HHS R01 AI151021
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T cells produce extraordinary remission rates in some hematologic tumors, results inconsistently replicated across malignancies and/or target antigens. Anti-tumor efficacy can be enhanced by modifying CAR architecture or T cell differentiation state. Pooled screening methods to identify effects of modifications are often restricted to

Indexed as

affinityATAC-seqbarcodingCAR T cellschromatinLeukemiatonic signaling

Identifiers

PMID42427866
PMCPMC13345528

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.