ArticleResearch square2026
Microsaccade Dynamics Enhance Nodule Detection and Discriminate Reader Expertise Levels During Chest Radiography.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background: Perceptual misses are a major source of diagnostic error in radiology, yet no physiological biomarker currently exists for expertise in chest radiograph interpretation. Purpose: To determine whether microsaccade dynamics enhance pulmonary nodule detection and discriminate reader expertise levels during chest radiography. Materials and Methods: In this experimental eye-tracking study, 26 adults (nine naive observers, 11 radiology residents, and six attending radiologists) searched for nodules in 148 chest radiographs from the Japanese Society of Radiological Technology database. Eye movements were recorded during image interpretation. Readers were analyzed by both training level and performance-based accuracy groups. Microsaccade dynamics were compared inside versus outside the nodule region and on correct versus incorrect trials. Receiver operating characteristic analyses were used to test whether oculomotor variables discriminated lower- from higher-accuracy readers. Results: On correct trials, across expertise levels, readers generated more microsaccades per fixation when viewing nodules than when viewing other image regions. This relationship was absent on incorrect trials, linking microsaccade production to successful abnormality detection. The effect remained after matching fixation durations inside and outside the target region, indicating that it was not explained solely by longer fixation times. Higher-accuracy readers also showed a greater prevalence of fixations containing microsaccades within the target region on correct trials. Receiver operating characteristic analyses identified a microsaccade-based oculomotor signature that differentiated lower- from higher-accuracy readers, including microsaccade rate within the target region on correct trials. Conclusion: Microsaccade dynamics enhance pulmonary nodule detection during chest radiography and provide, to our knowledge, the first microsaccade-based, largely non-volitional physiological biomarker of expertise in chest radiograph interpretation.
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