Evidence map›Paper›PMID 42427832›Full record

ArticleResearch square2026

First worldwide multicenter validation of the POLARIS preclinical polarizer across biological models and imaging paradigms.

Vencel Somai, Hadrien Dyvorne, Galen Reed, Christoph Mueller, Meret Cepero Malo, Catriona Rooney, Andrei Chekushkin, Senay Karaali, Zumrud Ahmadova, Martin Gierse and 47 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Vencel SomaiNVision Quantum Technologies.
Hadrien DyvorneNVision Quantum Technologies.
Galen ReedNVision Quantum Technologies.
Christoph MuellerNVision Quantum Technologies.
Meret Cepero MaloNVision Quantum Technologies.
Catriona RooneyNVision Quantum Technologies.
Andrei ChekushkinNVision Quantum Technologies.
Senay KaraaliNVision Quantum Technologies.
Zumrud AhmadovaNVision Quantum Technologies.
Martin GierseNVision Quantum Technologies.
Michael KeimNVision Quantum Technologies.
Jochen ScheuerNVision Quantum Technologies.
Jonas HandwerkerNVision Quantum Technologies.
Felix JostenNVision Quantum Technologies.
Saar SzekelyNVision Quantum Technologies.
Pascal RuettenNVision Quantum Technologies.
Luca NagelTechnical University of Munich.
Miriam KirstNVision Quantum Technologies.
Sandra SuehnelTechnical University of Munich.
Martin GrasheiTechnical University of Munich.
Franz SchillingTechnical University of Munich.
Stephen LaiThe University of Texas MD Anderson Cancer Center.
Qin WangThe University of Texas MD Anderson Cancer Center.
Yunyun ChenThe University of Texas MD Anderson Cancer Center.
James BanksonThe University of Texas MD Anderson Cancer Center.
David Gomez-CabezaInstitute for Bioengineering of Catalonia.
Lluis MangasInstitute for Bioengineering of Catalonia.
Gergo MatajszInstitute for Bioengineering of Catalonia.
Alba Herrero GómezInstitute for Bioengineering of Catalonia.
Vicent RibasInstitute for Bioengineering of Catalonia.
Irene Marco RiusInstitute for Bioengineering of Catalonia.
Renuka SriramUniversity of California, San Francisco.
Jeremy GordonUniversity of California, San Francisco.
Meetu WadhwaUniversity of California, San Francisco.
Xiao GaoUniversity of California, San Francisco.
Tamara VasilkovskaUniversity of California, San Francisco.
Daniel VigneronUniversity of California, San Francisco.
Andre WendlingerUniversity of Cambridge.
Joshua KaggieUniversity of Cambridge.
Ferdia GallagherUniversity of Cambridge.
Max BullockUniversity College London.
Rafat ChowdhuryUniversity College London.
Shonit PunwaniUniversity College London.
Ashley ShawWashington University in St. Louis.
James QuirkWashington University in St. Louis.
Nicholas Vidas-GuscicWashington University in St. Louis.
Madison HeadyWashington University in St. Louis.
Caroline GuglielmettiWashington University in St. Louis.
Cornelius von MorzeWashington University in St. Louis.
Mario ChangMemorial Sloan Kettering Cancer Center.
Saket PatelMemorial Sloan Kettering Cancer Center.
Roberta PigliapocchiMemorial Sloan Kettering Cancer Center.
Thasin PeyearMemorial Sloan Kettering Cancer Center.
Kayvan KeshariMemorial Sloan Kettering Cancer Center.
Ilai SchwartzNVision Quantum Technologies.
Stephan KnechtNVision Quantum Technologies.
Myriam ChaumeilNVision Quantum Technologies.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Leveraging fructose transport to create a privileged substrate to selectively fuel T cellsR01CA248364 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Kayvan R Keshari · 2021 to 2026
$4.3M
Development of large-field-of-view hyperpolarized MRIR01CA237466 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CUNNINGHAM, CHARLES H., HRICAK, HEDVIG · 2020 to 2024
$3.4M
Visualizing oxidative stress using hyperpolarized magnetic resonanceR01CA252037 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KESHARI, KAYVAN R · 2020 to 2024
$3.3M
Interrogation of the oxidative-stress-induced leukemia program in vivo usingmetabolic imagingR01CA283578 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Kayvan R Keshari, Michael Kharas · 2023 to 2026
$3.0M
Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapyR01CA249294 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI KESHARI, KAYVAN R, MERGHOUB, TAHA · 2021 to 2025
$2.6M
Replacement of a 4.7-T Small-Animal MRI Scanner with a 9.4-T SystemS10OD026913 · OD · WASHINGTON UNIVERSITY · PI ACKERMAN, JOSEPH J. H. · 2019 to 2019
$2.0M
High Field MRI For Optimized Translational 1H Multiparametric and Multinuclear Imaging ResearchS10OD030256 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN · 2021 to 2021
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA237466NCI NIH HHS R01 CA248364NCI NIH HHS R01 CA249294NCI NIH HHS R01 CA252037NCI NIH HHS R01 CA283578NIBIB NIH HHS P41 EB013598NIH HHS S10 OD026913NIH HHS S10 OD030256
6 · The paper itself

Abstract

Hyperpolarized

Indexed as

Hyperpolarized 13Chyperpolarized 13C Magnetic resonance imaginghyperpolarizermetabolic imagingparahydrogen-induced polarization via side-arm hydrogenation (PHIP-SAH)

Identifiers

PMID42427832
PMCPMC13345529

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.