Evidence map›Paper›PMID 42427815›Full record

ArticleHemaSphere2026

Short BRAF+MEK coinhibition, alone and combined with anti-CD20 immunotherapy, in relapsed or refractory hairy cell leukemia: An investigator-sponsored multi-center phase 2 clinical trial.

Luca De Carolis, Monia Capponi, Alessandro Mancini, Flavio Falcinelli, Caterina Stelitano, Alessandro Pulsoni, Edoardo Simonetti, Alessandra Romano, Gianna Maria D'Elia, Jacopo Olivieri and 15 more

Abstract readLetter
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Luca De CarolisInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Monia CapponiInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Alessandro ManciniInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.ORCID https://orcid.org/0000-0001-9144-8764
Flavio FalcinelliInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Caterina StelitanoHematology Hospital of Reggio Calabria Reggio Calabria Italy.
Alessandro PulsoniHematology Sapienza University of Rome and Hospital of Latina Latina Italy.
Edoardo SimonettiInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Alessandra RomanoHematology University and Hospital of Catania Catania Italy.
Gianna Maria D'EliaHematology Sapienza University and Hospital Umberto I of Rome Rome Italy.
Jacopo OlivieriHematology Clinic, ASUFC Udine Italy.
Maria Paola MartelliInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Alessandra PucciariniInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Alessia SantiInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Marta NaccariInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Alessandra VenanziInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Antonio BennatiInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Pier Luigi ZinzaniIRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia "Seràgnoli" Bologna Italy.ORCID https://orcid.org/0000-0002-2112-2651
Marzia VarettoniHematology IRCCS S. Matteo Pavia Italy.
Simone FerreroHematology University of Turin and Hospital "Città della Salute e della Scienza" of Turin Turin Italy.
Massimo PiniHematology S. Giovanni Bosco Hospital Turin Italy.
Robin FoàHematology Sapienza University and Hospital Umberto I of Rome Rome Italy.
Elisa LucchiniHematology Hospital of Trieste Trieste Italy.
Maurizio FrezzatoHematology Hospital of Vicenza Vicenza Italy.
Brunangelo FaliniInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.
Enrico TiacciInstitute of Hematology, Department of Medicine and Surgery University and Hospital of Perugia Perugia Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42427815
PMCPMC13348899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.