ArticlebioRxiv : the preprint server for biology2026
A Hypothalamic Inhibitory Circuit Encoding the Scalability of Stress Responses.
Yuhan Cao, Megumi H Seese, Zhiying Jiang, Cunjin Su, Maojie Yang, Fabricio H Do Monte, Qingchun Tong, Yuanzhong Xu
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Yuhan CaoBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Megumi H SeeseBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Zhiying JiangBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Cunjin SuBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Maojie YangBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Fabricio H Do MonteBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Qingchun TongBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Yuanzhong XuBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030.
Funding
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MR01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4MNeural Circuits Balancing Reward-Approaching with Threat-AvoidanceR01MH120136 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DO MONTE, FABRICIO HOFFMANN · 2020 to 2024
$2.8MHypothalamic CRH Neurons in Diet-induced ObesityR01DK135212 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Qingchun Tong · 2023 to 2026
$2.1M5-HT NEURONS INTEGRATE NEURAL INPUTS TO REGULATE FOOD INTAKER01DK120858 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TONG, QINGCHUN, XU, YONG · 2020 to 2023
$1.9MCorticothalamic circuits mediating behavioral adaptations to unexpected reward omissionR01MH131570 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BEIERLEIN, MICHAEL, DO MONTE, FABRICIO HOFFMANN · 2023 to 2025
$1.8MNeural pathways for obesity development by AgRP neuronsR01DK136284 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Qingchun Tong · 2023 to 2026
$1.8MA novel MC4R neural pathway in feedingR01DK131446 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2022 to 2025
$1.6MHypothalamic prodynorphin neurocircuits integrating defensive behaviorsR01MH139750 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Yuanzhong Xu · 2025 to 2026
$780kThe direct regulation of feeding-driving hypothalamic GABAergic neurons on stress responsesR21MH133228 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XU, YUANZHONG · 2024 to 2025
$429kNICHD NIH HHS U54 HD083092NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK120858NIDDK NIH HHS R01 DK131446NIDDK NIH HHS R01 DK135212NIDDK NIH HHS R01 DK136284NIMH NIH HHS R01 MH120136NIMH NIH HHS R01 MH131570NIMH NIH HHS R01 MH139750NIMH NIH HHS R21 MH133228
6 · The paper itselfAbstract
An appropriate stress response is essential for properly responding to, coping with, and subsequently recovering from disturbing environmental stimuli. However, how the brain dynamically encodes the scalability of stress responses remains poorly understood. Here, we found that, GABAergic neurons in the arcuate nucleus (Arc, denoted as Arc
Indexed as
Arcuate nucleusCRHGABAergicPVHScalabilityStress
Identifiers
PMID42427777
PMCPMC13345207
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390