Evidence map›Paper›PMID 42427743›Full record

ArticlebioRxiv : the preprint server for biology2026

Integrated multi-omics profiling of gut bacterial extracellular vesicles links cargo composition to host transcriptional responses.

Adarsh Singh, Yanjia Zhang, Jiucheng Ding, Qiaojuan Shi, Anas Saleh, Josh Jones, Xieyue Xiao, Yi-Yuan Lee, Kevin B Weyant, Matthew P DeLisa and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adarsh SinghNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-7826-8619
Yanjia ZhangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Jiucheng DingNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Qiaojuan ShiNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Anas SalehDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
Josh JonesNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Xieyue XiaoNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-6865-1534
Yi-Yuan LeeNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Kevin B WeyantRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.
Matthew P DeLisaNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Aaron TimpermanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Kyu Y RheeDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
Ilana L BritoNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

Funding

Data-driven discovery of host-microbiome protein-protein interactionsR01LM014714 · NLM · CORNELL UNIVERSITY · PI BRITO, ILANA LAUREN · 2025 to 2025
$1.8M
In Vivo Optical and MicroCT Imaging Instruments for the Cornell BRC Imaging FacilityS10OD025049 · OD · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2018 to 2018
$750k
NIH HHS S10 OD025049NLM NIH HHS R01 LM014714
6 · The paper itself

Abstract

Bacterial extracellular vesicles (bEVs) enable gut microbiota to deliver bioactive cargo to host cells, yet the specific bacterial producers have not been systematically identified. Here, we profiled stool-derived bEVs from healthy individuals using metaproteomic profiling, revealing that vesiculation is widespread across gut bacterial phyla. We selected a subset of vesiculating species, showing that bEVs localize to distinct tissues

Identifiers

PMID42427743
PMCPMC13345354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.