Evidence map›Paper›PMID 42427720›Full record

ArticlebioRxiv : the preprint server for biology2026

Inhibition of delta-1 glutamate receptor current by extracellular protons.

Andrew G Kain, Joe P Deuitch, Ayank Maiti, Stephanie C Gantz

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew G KainDepartment of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa; Iowa City, Iowa, 52242, USA.ORCID 0000-0002-8712-6735
Joe P DeuitchDepartment of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa; Iowa City, Iowa, 52242, USA.ORCID 0009-0005-7190-9400
Ayank MaitiDepartment of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa; Iowa City, Iowa, 52242, USA.
Stephanie C GantzDepartment of Molecular Physiology & Biophysics, Carver College of Medicine, University of Iowa; Iowa City, Iowa, 52242, USA.ORCID 0000-0002-1800-4400

Funding

Predoctoral Training in the Pharmacological SciencesT32GM144636 · NIGMS · UNIVERSITY OF IOWA · PI David L. Roman, STEFAN STRACK · 2022 to 2026
$1.9M
Regulation of monoamine neurons by delta glutamate receptorsR37DA060149 · NIDA · UNIVERSITY OF IOWA · PI Stephanie C. Gantz · 2024 to 2026
$1.5M
NIDA NIH HHS R37 DA060149NIGMS NIH HHS T32 GM144636
6 · The paper itself

Abstract

Decreases in brain pH are associated with numerous neurological and neuropsychiatric conditions yet the molecular mechanisms linking decreased brain pH with these disorders are incomplete. The ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission in the brain and are inhibited by extracellular protons; however, the proton sensitivity of the delta-glutamate receptor subclass of iGluRs is unknown. Using whole-cell patch-clamp recordings of serotonin neurons in mouse brain slices and activating alpha 1-adrenergic receptors to induce delta 1 glutamate receptor (GluD1

Identifiers

PMID42427720
PMCPMC13344944

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.