Evidence map›Paper›PMID 42427712›Full record

ArticlebioRxiv : the preprint server for biology2026

SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function.

Kim Han, Rachael J Klein, Kaiyuan Wu, Anna Chiara Russo, Allison M Meadows, Thomas C Recupero, Rahul Sharma, Anand K Gupta, Nathan T Brandes, Benjamin Schwarz and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kim HanLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Rachael J KleinLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Kaiyuan WuLaboratory of Obesity and Metabolic Diseases, NHLBI, NIH, Bethesda, MD, USA.
Anna Chiara RussoLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Allison M MeadowsLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Thomas C RecuperoLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Rahul SharmaLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Anand K GuptaLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Nathan T BrandesResearch Technologies Branch, NIAID, NIH, Hamilton, MT, USA.
Benjamin SchwarzResearch Technologies Branch, NIAID, NIH, Hamilton, MT, USA.
Michael N SackLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.ORCID 0000-0002-3411-0000

Funding

Mitochondrial biology in diabetesZIAHL005199 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2009 to 2025
$17.2M
Intramural NIH HHS ZIA HL005199
6 · The paper itself

Abstract

NAD

Indexed as

Arginine biosynthesisArginosuccinate lyaseCD4+ T cellsGlutarylationImmunometabolismNAD+ metabolismSIRT5

Identifiers

PMID42427712
PMCPMC13345334

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.