ArticlebioRxiv : the preprint server for biology2026
Hippocampal microcircuits constrain the generation of epileptiform activity.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epilepsy is largely characterized using macroscale measures of neural activity, such as electroencephalography, which are unable to resolve the underlying cellular-level substrates of pathological activity. Although there is a growing understanding that hippocampal microcircuits, comprised of distinct CA1 principal cells (PCs), inhibitory neurons, and input/output relationships, route information through parallel hippocampal pathways, the relevance of this microscale organization in epilepsy is poorly understood. To address this gap, we focally knocked out the β3 subunit of the GABA
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