Evidence map›Paper›PMID 42427673›Full record

ArticlebioRxiv : the preprint server for biology2026

Protein Surface Site Determines the Evolutionary Accessibility of Allosteric Regulation.

Jerry C Dinan, James W McCormick, Rishi Soni, Samuel Thompson, Kimberly A Reynolds

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jerry C DinanThe Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-5660-1444
James W McCormickThe Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-7573-2300
Rishi SoniThe T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218.ORCID 0009-0009-2516-2229
Samuel ThompsonDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.ORCID 0000-0001-6468-9538
Kimberly A ReynoldsThe Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-4805-0317

Funding

Cellular and Molecular BiologyT32GM141804 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI John Kim · 2021 to 2026
$5.1M
Molecular Biophysics Training ProgramT32GM131963 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Luke W Rice · 2019 to 2026
$1.5M
NIGMS NIH HHS T32 GM131963NIGMS NIH HHS T32 GM141804
6 · The paper itself

Abstract

Domain recombination is a major source of new allosteric regulation in both evolved and engineered proteins. However, the sequence and structural features that govern where new allostery may emerge remain poorly understood. Here, we test the hypothesis that the evolutionary accessibility of allosteric regulation following domain insertion is constrained by local surface context, specifically association with pre-existing cooperative networks known as protein sectors. We began with two synthetic domain fusions wherein the

Indexed as

AllosteryDeep Mutational ScanDomain InsertionEvolvabilityProtein Regulation

Identifiers

PMID42427673
PMCPMC13344980

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.