Evidence map›Paper›PMID 42427669›Full record

ArticlebioRxiv : the preprint server for biology2026

Resident myeloid-derived immune cells contribute to early lipopolysaccharide-induced cytokine secretion in mouse soleus muscle.

Finleigh P Fitton, Deborah A Morse, Kevin J Cusack, Bryce J Gambino, Thomas L Clanton

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Finleigh P FittonDepartment of Applied Physiology and Kinesiology, the University of Florida, Gainesville FL, 32611.
Deborah A MorseDepartment of Applied Physiology and Kinesiology, the University of Florida, Gainesville FL, 32611.
Kevin J CusackDepartment of Applied Physiology and Kinesiology, the University of Florida, Gainesville FL, 32611.
Bryce J GambinoDepartment of Applied Physiology and Kinesiology, the University of Florida, Gainesville FL, 32611.
Thomas L ClantonDepartment of Applied Physiology and Kinesiology, the University of Florida, Gainesville FL, 32611.ORCID 0000-0003-0600-7150

Funding

Functional Role of Skeletal Muscle in the Innate Immune to SepsisR01GM118895 · NIGMS · UNIVERSITY OF FLORIDA · PI CLANTON, THOMAS LINDSAY · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM118895
6 · The paper itself

Abstract

Skeletal muscles secrete a variety of cytokines in response to inflammatory stimuli such as lipopolysaccharide (LPS); however, the contributions of resident macrophages or other non-muscle cells to the secretory responses are not well understood. Here we tested the LPS responsiveness of mouse soleus when a critical toll receptor adapter protein (Myd88) was knocked down only in myeloid-derived cells (e.g. resident macrophages). The phenotype is referred to as LyzMyd88

Indexed as

endotoxinmacrophagemacrophage polarizationmyo-immune axisMyokinesepsisseptic shockskeletal muscle fibers

Identifiers

PMID42427669
PMCPMC13345146

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.