Evidence map›Paper›PMID 42427665›Full record

ArticlebioRxiv : the preprint server for biology2026

Aberrant neuronal differentiation and splicing defects in Congenital Myotonic Dystrophy (DM1) iPSC models.

Surya Chandra Rao Thumu, Jean Patrick Gonzales, Soha Munir, Connor Tuck, Oscar Dominguez, Sandeep K Singh

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Surya Chandra Rao ThumuDepartment of Cellular, Molecular and Genetic Medicine, Virginia commonwealth University School of Medicine, Richmond, Virginia, USA.
Jean Patrick GonzalesDepartment of Cellular, Molecular and Genetic Medicine, Virginia commonwealth University School of Medicine, Richmond, Virginia, USA.
Soha MunirDepartment of Cellular, Molecular and Genetic Medicine, Virginia commonwealth University School of Medicine, Richmond, Virginia, USA.
Connor TuckDepartment of Cellular, Molecular and Genetic Medicine, Virginia commonwealth University School of Medicine, Richmond, Virginia, USA.
Oscar DominguezDepartment of Cellular, Molecular and Genetic Medicine, Virginia commonwealth University School of Medicine, Richmond, Virginia, USA.
Sandeep K SinghDepartment of Cellular, Molecular and Genetic Medicine, Virginia commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID 0000-0002-8069-6452

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
URM Student supplement - R01 NS126504 SSinghR01NS126504 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Sandeep Kumar Singh · 2022 to 2026
$2.3M
NCI NIH HHS P30 CA016059NINDS NIH HHS R01 NS126504
6 · The paper itself

Abstract

Myotonic Dystrophy type 1 (DM1) is an autosomal multisystem disorder manifested due to unstable CTG nucleotide repeat expansion within the 3'-untranslated region of the dystrophia myotonica protein kinase (

Indexed as

Alternative splicingiPSCsMBNL1MBNL2Myotonic dystrophy (DM1)neurogenic signature

Identifiers

PMID42427665
PMCPMC13344955

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.