Evidence map›Paper›PMID 42427658›Full record

ArticlebioRxiv : the preprint server for biology2026

Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity.

Koichiro Haruwaka, Juan Liu, Yue Liang, Shinya Matsumoto, Dimitrios Kleidonas, Wu Shi, Shunyi Zhao, Yong U Liu, Anthony D Umpierre, Zhongcong Xie and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Koichiro HaruwakaCenter for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-1484-6990
Juan LiuBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102206, China.
Yue LiangCenter for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Shinya MatsumotoCenter for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Dimitrios KleidonasCenter for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Wu ShiCenter for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Shunyi ZhaoCenter for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Yong U LiuLaboratory for Neuro-glial Homeostasis and Disease, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Anthony D UmpierreDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Zhongcong XieDepartment of Anesthesiology, Critical Care and Pain Medicine, Center for Aging and Cognitive Dysfunction, Institute of Perioperative Medicine, The University of Texas Health Science Center, Houston, Texas, USA.
Miao JingBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102206, China.
Long-Jun WuCenter for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-8019-3380

Funding

Pathogenesis of Postoperative Cognitive DysfunctionR01AG041274 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongcong Xie, Guang Yang · 2012 to 2026
$6.7M
How microglia sense and regulate neuronal activity in the adult brainR35NS132326 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Long-Jun Wu · 2023 to 2026
$3.2M
NIA NIH HHS R01 AG041274NINDS NIH HHS R35 NS132326
6 · The paper itself

Abstract

How glial cells sense and regulate neuronal hypoactivity remains poorly understood. Using in vivo imaging in anesthetized, sleeping, and behaving mice, we identified a glial purinergic signaling mechanism that converts neuronal hypoactivity into local circuit regulation. Cortical hypoactivity increased spatially confined ATP release through astrocytic pannexin-1 hemichannels, which were structurally enriched near perisomatic parvalbumin-positive boutons. Local ATP release directed microglial process movement and stabilized bulbous endings through microglial P2Y12 signaling, accompanied by localized Ca

Identifiers

PMID42427658
PMCPMC13345158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.