Evidence map›Paper›PMID 42427650›Full record

ArticlebioRxiv : the preprint server for biology2026

Opportunistic pathogenicity in fungi can transcend species boundaries.

David C Rinker, Thomas J C Sauters, Adiyantara Gumilang, Olivia L Riedling, Karin Steffen, Camila Figueiredo Pinzan, Thaila Reis, Patrícia Alves de Castro, Manuel Rangel-Grimaldo, Huzefa A Raja and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

David C RinkerDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0001-5894-7633
Thomas J C SautersDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0001-9524-2288
Adiyantara GumilangDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0002-8887-9763
Olivia L RiedlingDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
Karin SteffenDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0003-0499-1430
Camila Figueiredo PinzanFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Thaila ReisFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-7776-977X
Patrícia Alves de CastroFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Manuel Rangel-GrimaldoDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
Huzefa A RajaDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.ORCID 0000-0002-0824-9463
John G GibbonsDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts, USA.ORCID 0000-0003-1282-9345
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.ORCID 0000-0002-0354-8464
Gustavo H GoldmanFaculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-2986-350X
Antonis RokasDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0002-7248-6551

Funding

Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5M
NIAID NIH HHS R01 AI153356
6 · The paper itself

Abstract

Multiple fungal lineages have independently evolved the ability to opportunistically infect humans, imposing a major burden on public health. Opportunistic pathogenicity requires the confluence of pre-existing fungal traits that facilitate host colonization (

Indexed as

comparative genomicsevolution of virulencefungal pathogenicitymedical mycologysecondary metabolism

Identifiers

PMID42427650
PMCPMC13345210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.