Evidence map›Paper›PMID 42427649›Full record

ArticlebioRxiv : the preprint server for biology2026

Simultaneous Functional Ultrasound, Intrinsic Optical Signal and Widefield Calcium Neuroimaging.

Shubham Mirg, Prameth Gaddale, Achutha Kumar, Krishnendu Samanta, Bhawna Saini, Saniya P Patil, Ana A Vargas, Aayushi Laliwala, Agata A Exner, Yong Wang and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shubham MirgDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.ORCID 0000-0003-1811-6047
Prameth GaddaleDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.ORCID 0000-0002-5381-8098
Achutha KumarDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.
Krishnendu SamantaDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.ORCID 0000-0002-9657-6519
Bhawna SainiDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.ORCID 0009-0007-4453-488X
Saniya P PatilDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.
Ana A VargasDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.
Aayushi LaliwalaDepartment of Radiology, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID 0000-0002-6472-4070
Agata A ExnerDepartment of Radiology, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID 0000-0003-3913-7066
Yong WangDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.
Grayson O SipeDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.ORCID 0000-0002-1553-7068
Sri-Rajasekhar KothapalliDepartment of Biomedical Engineering, Pennsylvania State University, PA 16802, USA.ORCID 0000-0002-4010-1047

Funding

Cross-Disciplinary Neural Engineering (CDNE) Training ProgramT32NS115667 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI GLUCKMAN, BRUCE J · 2021 to 2025
$1.1M
NINDS NIH HHS T32 NS115667
6 · The paper itself

Abstract

Functional ultrasound (fUS) maps cerebral blood volume (CBV) but lacks molecular and neuronal specificity. By simultaneously integrating fUS with optical imaging, we show that fUS-derived CBV correlates with both optically measured hemoglobin and neuronal calcium activity in awake mice. We further derive hemodynamic response functions linking calcium activity to CBV during spontaneous and sensory-evoked activity. Application to a mouse glioblastoma model demonstrates utility for studying neurovascular dysfunction in complex neuropathologies.

Identifiers

PMID42427649
PMCPMC13345001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.