ArticlebioRxiv : the preprint server for biology2026
iPSC Neurodegenerative Disease Initiative isogenic CAG repeat iPSC line for Huntington's disease.
Lisa Salazar, Mara S Burns, Jennifer T Stocksdale, Keona Q Wang, Gloria Cao, Ricardo Miramontes, Nicolette R McClure, Leanne Ho, Amber Rose Keith, Margaret Sutherland and 4 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Lisa SalazarSue and Bill Gross Stem Cell Center, UC Irvine.
Mara S BurnsDepartment of Neurobiology and Behavior, UC Irvine.
Keona Q WangDepartment of Neurobiology and Behavior, UC Irvine.
Gloria CaoDepartment of Neurobiology and Behavior, UC Irvine.
Ricardo MiramontesUCI Memory Impairments and Neurological Disorders (MIND), UC Irvine.
Nicolette R McClureDepartment of Neurobiology and Behavior, UC Irvine.
Leanne HoSue and Bill Gross Stem Cell Center, UC Irvine.
Amber Rose KeithDepartment of Neurobiology and Behavior, UC Irvine.
Margaret SutherlandCZI Biohub.
Mark R CooksonCenter for Alzheimer's Disease and Related Dementias (CARD), National Institute on Aging, National Institutes of Health.ORCID 0000-0002-1058-3831 Michael WardCenter for Alzheimer's Disease and Related Dementias (CARD), National Institute on Aging, National Institutes of Health.ORCID 0000-0002-5296-8051 Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MiPSC Neurodegenerative Diseasses InitiativeZIAAG000535 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2019 to 2025
$48.2MMolecular Mechanisms of Pathogenesis in Huntington’s diseaseR35NS116872 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Leslie Michels Thompson · 2020 to 2026
$8.5MEpigenetic Pathology and Therapy in Huntington's DiseaseR01NS089076 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FRAENKEL, ERNEST, HOUSMAN, DAVID · 2015 to 2024
$4.9MTraining Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3MNeuroimmunology Training Program at the University of California, IrvineT32NS121727 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, Thomas E Lane · 2022 to 2026
$854kEffect of Mutant HTT on the Development and Maturation of AstrocytesF31NS134306 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BURNS, MARA · 2024 to 2025
$93kIntramural NIH HHS ZIA AG000535NCI NIH HHS P30 CA062203NINDS NIH HHS F31 NS134306NINDS NIH HHS R01 NS089076NINDS NIH HHS R35 NS116872NINDS NIH HHS T32 NS082174NINDS NIH HHS T32 NS121727
6 · The paper itselfAbstract
Purpose of Research: The generation of iPSC lines expressing 21, 56 and 79 glutamine repeats within the HTT protein and homozygous KO of Major Findings: All iPSCs, even those expressing long repeats of 79Q or Conclusions: The KOLF2.1J isogenic CAG repeat series serves as a community resource to study HD mechanisms with the potential for direct comparison across other neurodegenerative diseases through the iNDI collection.
Indexed as
astrocyteCRISPRdifferentiationHuntingtiniNDIiPSCmicroglianeuron
Identifiers
PMID42427629
PMCPMC13345184
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