Evidence map›Paper›PMID 42427622›Full record

ArticlebioRxiv : the preprint server for biology2026

Enhanced TRPV1 activation through TLR-4 and PKA signaling in Dorsal Root Ganglia Neurons.

Julia Borges Paes Lemes, Kauê Franco Malange, Alisa Panichkina, Juliana Navia-Pelaez, Soo-Ho Choi, Maksim Dolmat, Gilson Gonçalves Dos Santos, Sara Dochnal, Maripat Corr, Yury I Miller and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia Borges Paes LemesDepartment of Anesthesiology, University of California, San Diego, CA, USA.ORCID 0000-0003-2212-6803
Kauê Franco MalangeDepartment of Anesthesiology, University of California, San Diego, CA, USA.ORCID 0000-0001-5381-6730
Alisa PanichkinaDepartment of Anesthesiology, University of California, San Diego, CA, USA.
Juliana Navia-PelaezDepartment of Medicine, University of California, San Diego, CA, USA.ORCID 0000-0001-5709-339X
Soo-Ho ChoiDepartment of Medicine, University of California, San Diego, CA, USA.
Maksim DolmatDepartment of Chemical and Nano Engineering, University of California, San Diego, CA, USA.ORCID 0000-0002-4918-7342
Gilson Gonçalves Dos SantosDepartment of Anesthesiology, University of California, San Diego, CA, USA.ORCID 0000-0002-2704-3006
Sara DochnalDepartment of Anesthesiology, University of California, San Diego, CA, USA.ORCID 0000-0003-3011-567X
Maripat CorrDepartment of Medicine, University of California, San Diego, CA, USA.
Yury I MillerDepartment of Medicine, University of California, San Diego, CA, USA.ORCID 0000-0003-0521-7690
Tony YakshDepartment of Anesthesiology, University of California, San Diego, CA, USA.ORCID 0000-0003-4297-536X

Funding

Role of TLR4-lipid rafts in nociceptionR01NS132483 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Patrick M Dougherty, Yury Miller · 2024 to 2026
$2.3M
NINDS NIH HHS R01 NS132483
6 · The paper itself

Abstract

The excitability of afferents involved in nociceptive signaling reflects the interaction of several co-expressed membrane receptors. Current studies have shown that Toll-like receptor-4 (TLR-4) signaling can exacerbate excitation evoked by transient receptor potential vanilloid type 1 (TRPV1) activity, and this interaction plays a key role in driving and sustaining facilitated pain states. The mechanism by which this potentiated TRPV1 activity secondary to TLR-4 agonism occurs in sensory neurons remains unknown, although intracellular kinase activity is a strong candidate. To address this hypothesized linkage, neuronal cell cultures prepared from dorsal root ganglia (DRG) of male wildtype (WT) and

Indexed as

capsaicinDRGLPSnociceptorsPKATLR-4TRPV1

Identifiers

PMID42427622
PMCPMC13345121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.