ArticlebioRxiv : the preprint server for biology2026
ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation.
Katherine Bronson, Milla M Reddick, Kenzie B MacNicol, Cole Bolen, Linda Hardy, Alex Lagasse, Angela K Odle, Gwen V Childs, Melanie C MacNicol, Angus M MacNicol
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Katherine BronsonDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.
Milla M ReddickDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.
Kenzie B MacNicolDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.
Cole BolenDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.
Linda HardyDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.
Alex LagasseDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.
Angela K OdleDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.ORCID 0000-0001-5017-9676 Gwen V ChildsDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.ORCID 0000-0003-3764-1373 Melanie C MacNicolDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.ORCID 0000-0001-6927-2475 Angus M MacNicolDepartment of Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.ORCID 0000-0003-4812-9519 Funding
Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6MInstitutional Career DevelopmentKL2TR003108 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI ARTHUR, JOHN M., BORSHEIM, ELISABET · 2019 to 2023
$2.3MMolecular mechanisms of pituitary plasticityR01DK139476 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI GWEN V CHILDS, MELANIE C MACNICOL · 2024 to 2026
$1.9MJ. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5MNCATS NIH HHS KL2 TR003108NCATS NIH HHS TL1 TR003109NCATS NIH HHS UL1 TR003107NIDDK NIH HHS R01 DK139476
6 · The paper itselfAbstract
The RNA-binding proteins Musashi1 and Musashi2 (MSI1 and MSI2) regulate stem cell function and tissue plasticity by modulating mRNA translation. While typically known as translational repressors, the MSI1 and MSI2 proteins can also act as context-dependent activators of mRNA translation, although the mechanism of MSI-mediated translational activation are unknown. Here, we identify Embryonic Lethal Abnormal Vision-like (ELAVL) proteins as essential co-regulators of MSI1-dependent translational activation. In
Indexed as
ELAVLmRNA translationMSIoocytepituitary
Identifiers
PMID42427619
PMCPMC13345177
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