Evidence map›Paper›PMID 42427584›Full record

ArticlebioRxiv : the preprint server for biology2026

Substrate recognition, not sequestration, drives the engagement of an H3K9 methyltransferase in living cells.

Yekaterina Fyodorova, Samuel B Steen, Alexander Levashkevich, Luis A Ortiz-Rodríguez, Sumanth Kumar Maheshwaram, Serena Chiu, Kaushik Ragunathan, Julie S Biteen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yekaterina FyodorovaUniversity of Michigan Department of Chemistry, Ann Arbor, MI 48109.ORCID 0000-0002-3823-0464
Samuel B SteenUniversity of Michigan Program in Chemical Biology, Ann Arbor, MI 48109.ORCID 0009-0004-1131-4774
Alexander LevashkevichDepartment of Biology, Brandeis University, Waltham, MA 02451.ORCID 0009-0009-0537-8372
Luis A Ortiz-RodríguezUniversity of Michigan Department of Chemistry, Ann Arbor, MI 48109.ORCID 0000-0002-4901-6439
Sumanth Kumar MaheshwaramDepartment of Biology, Brandeis University, Waltham, MA 02451.ORCID 0000-0002-5379-7223
Serena ChiuDepartment of Biology, Brandeis University, Waltham, MA 02451.
Kaushik RagunathanDepartment of Biology, Brandeis University, Waltham, MA 02451.ORCID 0000-0003-4776-8589
Julie S BiteenUniversity of Michigan Department of Chemistry, Ann Arbor, MI 48109.ORCID 0000-0003-2038-6484

Funding

Heterochromatin dynamics during inheritance and adaptationR35GM137832 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kaushik Ragunathan · 2020 to 2026
$3.2M
NIGMS NIH HHS R35 GM137832
6 · The paper itself

Abstract

The histone H3K9 methyltransferase Clr4 is essential for heterochromatin formation in

Identifiers

PMID42427584
PMCPMC13344961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.