Evidence map›Paper›PMID 42427580›Full record

ArticlebioRxiv : the preprint server for biology2026

Paralogs of the

Emily Simonton, Nayeli Cangelosi, Mikki Zhou, Philip S Hendricks, Andrew L Woodruff, Matthew Z Anderson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily SimontonMicrobiology Doctoral Training Program, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0003-1096-5239
Nayeli CangelosiLaboratory of Genetics, University of Wisconsin - Madison, Madison, WI, USA.
Mikki ZhouLaboratory of Genetics, University of Wisconsin - Madison, Madison, WI, USA.
Philip S HendricksDepartment of Microbiology, The Ohio State University, Columbus, OH, USA.ORCID 0009-0002-4096-8588
Andrew L WoodruffDepartment of Microbiology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-5818-360X
Matthew Z AndersonDepartment of Microbiology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-1683-2170

Funding

Quantitative genetic approaches to Candida albicans pathogenesisR01AI148788 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDERSON, MATTHEW Z · 2020 to 2024
$2.2M
Defining the role of the TLO gene family in Candida albicans parasexual processesF31AI167576 · NIAID · OHIO STATE UNIVERSITY · PI WOODRUFF, ANDREW LOGAN · 2022 to 2023
$63k
NIAID NIH HHS F31 AI167576NIAID NIH HHS R01 AI148788
6 · The paper itself

Abstract

Gene duplication typically fails to confer a selective advantage to an organism, prompting their removal from a population. In the rare instance that duplication either does not incur a fitness cost or it enhances fitness, gene families can form through repeating the duplication process. While the function of gene duplicates has been studied in detail, little work has explored how repeated duplication impacts paralog redundancy and may restrict the emergence of new paralogs or novel function. Here, we constructed a panel of single deletion mutants for each of the 14 members of the

Indexed as

Candida albicansexpanded gene familiesgene duplicationredundancysynergy

Identifiers

PMID42427580
PMCPMC13344963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.