Evidence map›Paper›PMID 42427579›Full record

ArticlebioRxiv : the preprint server for biology2026

Indirect genomic effects shape cancer risk across species.

George Butler, Srividya Ramakrishnan, Tyler Collins, Joanna Baker, Sarah R Amend, Vertebrate Genomes Project Consortium Phase I, Michael C Schatz, Chris Venditti, Kenneth J Pienta

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

George ButlerUniversity College London Cancer Institute, University College London, London, United Kingdom.ORCID 0000-0002-6207-6225
Srividya RamakrishnanDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, United States of America.ORCID 0000-0001-8023-4752
Tyler CollinsDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, United States of America.ORCID 0000-0002-3026-9049
Joanna BakerSchool of Life, Health, and Chemical Sciences, The Open University, Milton Keynes, United Kingdom.ORCID 0000-0003-4904-6934
Sarah R AmendThe Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0002-5606-1262
Vertebrate Genomes Project Consortium Phase I
Michael C SchatzDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, United States of America.ORCID 0000-0002-4118-4446
Chris VendittiSchool of Biological Science, University of Reading, Reading, United Kingdom.ORCID 0000-0002-6776-2355
Kenneth J PientaThe Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0002-4138-2186

Funding

Implementing the Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL)U24HG010263 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI Enis Afgan, VINCENT JAMES CAREY · 2018 to 2026
$23.8M
Democratization of Data Analysis in Life Sciences Through GalaxyU41HG006620 · NHGRI · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEKRUTENKO, ANTON, SCHATZ, MICHAEL · 2012 to 2020
$14.4M
SPORE in Prostate CancerP50CA272391 · NCI · JOHNS HOPKINS UNIVERSITY · PI Samuel R Denmeade, SHAWN LUPOLD · 2024 to 2026
$9.0M
Developing a Cancer Galaxy Computational Workbench to Meet Emerging Cancer Data Analysis NeedsU24CA284167 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Jeremy Goecks · 2024 to 2026
$2.9M
NCI NIH HHS P50 CA272391NCI NIH HHS U24 CA284167NHGRI NIH HHS U24 HG010263NHGRI NIH HHS U41 HG006620
6 · The paper itself

Abstract

Tumour prevalence varies dramatically throughout the animal kingdom despite broadly conserved cellular and developmental processes, raising the question of how evolution has shaped susceptibility

Identifiers

PMID42427579
PMCPMC13345119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.