ArticlebioRxiv : the preprint server for biology2026
Legacy Effects of Early β-Adrenergic Stimulation Program Adipose Plasticity and Confer Metabolic Resilience in Obesity.
Abstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Pablo E MoralesDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Wenxin TongDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Lavanya VishvanathDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Danielle C LeanderDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Taylor E WadeDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
David S HallaronDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Kimberley ElDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Robert A HollanderDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Ashley TruongDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Donald WotheDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
George ElmquistDepartment of Internal Medicine, Touchstone Diabetes Center, University of Texas Southwestern Medical Center; Dallas, TX, USA.
Marjori RussoDepartment of Cell Biology and Physiology, Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.
Heather K HamilosDiabetes and Metabolism Research Center, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
Grace E DewyerDiabetes and Metabolism Research Center, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
Clair CreweDepartment of Cell Biology and Physiology, Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.
William L HollandDiabetes and Metabolism Research Center, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
Timothy R KovesDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Deborah M MuoioDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
David A D'AlessioDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Jessica CannavinoDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Jonathan E CampbellDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Mengle ShaoDepartment of Internal Medicine, Touchstone Diabetes Center, University of Texas Southwestern Medical Center; Dallas, TX, USA.
Rana K GuptaDuke Molecular Physiology Institute, Division of Endocrinology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MTRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2MPilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI P Darrell Neufer · 2020 to 2026
$11.0MENGINEERED GLUCOSE METABOLISM IN INSULIN-SECRETING CELLSR01DK046492 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI NEWGARD, CHRISTOPHER B · 1993 to 2025
$7.8MEstablishment and Maintenance of Healthy Adipose Tissue in ObesityR01DK104789 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2015 to 2024
$3.9MEngineered Glucose Metabolism in Insulin Secreting CellsR37DK046492 · NIDDK · DUKE UNIVERSITY · PI NEWGARD, CHRISTOPHER B · 2003 to 2010
$3.5MLiver-islet and intra-islet cross talk in alpha cell hyperplasia and beta cell regenerationR01DK112826 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HOLLAND, WILLIAM L · 2017 to 2025
$3.4MNovel metabolic actions of GIPR01DK125353 · NIDDK · DUKE UNIVERSITY · PI CAMPBELL, JONATHAN E, D'ALESSIO, DAVID A. · 2020 to 2024
$2.1MAlpha- to Beta-Cell Communication in Health and DiseaseR01DK142423 · NIDDK · DUKE UNIVERSITY · PI Jonathan E Campbell, DAVID A. D'ALESSIO · 2024 to 2026
$1.9MMechanisms of insulin secretion mediated by alpha cellsR01DK123075 · NIDDK · DUKE UNIVERSITY · PI CAMPBELL, JONATHAN E · 2019 to 2023
$1.9MSphingolipid-Mediated Dysregulation of Glucose and Energy Homeostasis in the CNSR01DK108833 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HOLLAND, WILLIAM L · 2016 to 2020
$1.8MRegulation of Adipose Tissue Plasticity by Pericyte GIPRR01DK143978 · NIDDK · DUKE UNIVERSITY · PI Jonathan E Campbell, Rana K Gupta · 2025 to 2026
$1.6MNIBIB NIH HHS R21 EB035738NIDDK NIH HHS F30 DK136168NIDDK NIH HHS K01 DK132461NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK124723NIDDK NIH HHS P60 DK020579NIDDK NIH HHS R01 DK046492NIDDK NIH HHS R01 DK104789NIDDK NIH HHS R01 DK108833NIDDK NIH HHS R01 DK112826NIDDK NIH HHS R01 DK123075NIDDK NIH HHS R01 DK125353NIDDK NIH HHS R01 DK137791NIDDK NIH HHS R01 DK142423NIDDK NIH HHS R01 DK143978NIDDK NIH HHS R37 DK046492
Abstract
Pathologic white adipose tissue (WAT) remodeling, characterized by fibrosis, inflammation, and adipocyte dysfunction, is a hallmark and driver of metabolic disease in obesity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.