Evidence map›Paper›PMID 42427563›Full record

ArticlebioRxiv : the preprint server for biology2026

Maintenance DNA methylation is necessary for age-related alterations in regulatory T cell transcriptional and DNA methylation signatures.

Jonathan K Gurkan, Qianli Liu, Carla P Reyes Flores, Kathryn A Helmin, Daniel H Ryan, Anthony M Joudi, Benjamin J Ulrich, Hiam Abdala-Valencia, Elizabeth M Steinert, Benjamin D Singer

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan K GurkanDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0002-0149-3463
Qianli LiuDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0002-7629-5648
Carla P Reyes FloresDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0001-9016-3257
Kathryn A HelminDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0009-0006-8857-9943
Daniel H RyanDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0009-0006-4795-1681
Anthony M JoudiDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0003-1232-3256
Benjamin J UlrichDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0002-2729-1798
Hiam Abdala-ValenciaDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0003-3384-5299
Elizabeth M SteinertDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0002-6947-2271
Benjamin D SingerDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.ORCID 0000-0001-5775-8427

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHARD G WUNDERINK · 2018 to 2026
$24.7M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways DiseasesU19AI181102 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, Alexander Misharin · 2024 to 2026
$9.3M
Medical Scientist Training ProgramT32GM144295 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2022 to 2026
$9.1M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
FACSAria SORP Cell SorterS10OD011996 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOOLSBY, CHARLES L. · 2012 to 2012
$482k
The role of epigenetic regulator UHRF1 in stability of induced regulatory T-cell function during influenza A virus-induced lung injuryF32HL162418 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JOUDI, ANTHONY · 2022 to 2025
$251k
Metabolic regulation of regulatory T cells through fatty acid metabolism during viral pneumoniaF30AI188691 · NIAID · NORTHWESTERN UNIVERSITY · PI Jonathan Kemal Gurkan · 2025 to 2026
$99k
NCI NIH HHS P30 CA060553NHLBI NIH HHS F32 HL162418NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS T32 HL076139NIAID NIH HHS F30 AI188691NIAID NIH HHS U19 AI135964NIAID NIH HHS U19 AI181102NIA NIH HHS P01 AG049665NIA NIH HHS U54 AG079754NIGMS NIH HHS T32 GM144295NIH HHS S10 OD011996
6 · The paper itself

Abstract

CD4

Identifiers

PMID42427563
PMCPMC13345046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.