Evidence map›Paper›PMID 42427561›Full record

ArticlebioRxiv : the preprint server for biology2026

Particle size determines mucociliary transport mechanisms in normal and cystic fibrosis airways.

Michael Scott, Kaleb C Bierstedt, Weijie Du, Mitchell J Riley, Anthony J Fischer, Yuliang Xie

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael ScottRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, USA.
Kaleb C BierstedtRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, USA.
Weijie DuDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, USA.
Mitchell J RileyDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, USA.
Anthony J FischerStead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, USA.
Yuliang XieRoy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, USA.

Funding

Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
An Engineered Surface of Mucociliary Transport for Medical DevicesR01EB033395 · NIBIB · UNIVERSITY OF IOWA · PI Yuliang Xie · 2023 to 2026
$1.3M
Initial Attachment of Bacteria to Mucus Strands in Cystic FibrosisK08HL136927 · NHLBI · UNIVERSITY OF IOWA · PI FISCHER, ANTHONY JOHN · 2017 to 2020
$639k
Developing Trachea-on-a-chip to Study Particle Mucociliary Transport in AirwaysR21HL161499 · NHLBI · UNIVERSITY OF IOWA · PI XIE, YULIANG · 2022 to 2023
$401k
NHLBI NIH HHS K08 HL136927NHLBI NIH HHS P01 HL091842NHLBI NIH HHS R21 HL161499NIBIB NIH HHS R01 EB033395
6 · The paper itself

Abstract

A wide spectrum of microparticles is inhaled with each breath, deposited on airway surfaces, entrapped in the mucus, and removed by mucociliary transport (MCT). However, the influence of particle size on MCT remains largely unknown. Here, we investigated the MCT of microparticles with a trachea-on-a-chip method that integrates a micro-machined device with a trachea explant from newborn pigs. This method preserves airway structures for mucus secretion and cilia beating (

Identifiers

PMID42427561
PMCPMC13345036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.