Evidence map›Paper›PMID 42427552›Full record

ArticlebioRxiv : the preprint server for biology2026

Sequential Penta-Omic Extraction Method Using Single Biospecimens of Post-mortem Human Brain.

Scott P Lyons, Brandie M Ehrmann, Thomas S Webb, Cristina Arciniega, Laura E Herring, Shengru Guo, Stuart Parnham, William K Scott, Piotr A Mieczkowski, Jeffrey M Macdonald

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Scott P LyonsDepartment of Pharmacology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Brandie M EhrmannDepartment of Chemistry, University of North Carolina, Chapel Hill, USA.
Thomas S WebbDepartment of Pharmacology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Cristina ArciniegaDepartment of Chemistry, University of North Carolina, Chapel Hill, USA.
Laura E HerringDepartment of Pharmacology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Shengru GuoJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Stuart ParnhamDepartment of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
William K ScottJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0001-9336-6404
Piotr A MieczkowskiDepartment of Genetics, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Jeffrey M MacdonaldLampe Joint UNC-NCSU Biomedical Engineering Department, School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
Validation of penta-omic assays in brain tissue and identification of markers of tissue and -omic data qualityR21AG088936 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACDONALD, JEFFREY M., MIECZKOWSKI, PIOTR ANDRZEJ · 2024 to 2024
$440k
NCI NIH HHS P30 CA016086NIA NIH HHS R21 AG088936NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

A multi-omic approach utilizing a single biospecimen is important to avoid intra-sample heterogeneity associated with testing multiple omic single-samples, and for more efficient use of small volumes of precious biopsies (<30 mg). This is especially true for the microanatomy of post-mortem human brain samples. Using post-mortem human brain biospecimens from the NIH NeuroBioBank, a penta-omic sequential extraction method is described,

Identifiers

PMID42427552
PMCPMC13345160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.