Evidence map›Paper›PMID 42427516›Full record

ArticlebioRxiv : the preprint server for biology2026

Collective fluctuations underlying nanobody inhibitory activity targeting

Adam J Cecil, Alexander J Pak

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Adam J CecilDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, USA.
Alexander J PakDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, USA.ORCID 0000-0003-2823-6480

Funding

Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Spatiotemporal dynamics of self-organizing protein complexes through a computational lensR35GM157192 · NIGMS · COLORADO SCHOOL OF MINES · PI Alexander Pak · 2025 to 2026
$675k
Multiscale Modeling of B. Anthracis Surface Layer Assembly and Depolymerization by NanobodiesR21AI168838 · NIAID · COLORADO SCHOOL OF MINES · PI PAK, ALEXANDER · 2022 to 2023
$393k
NIAID NIH HHS R21 AI168838NIGMS NIH HHS R01 GM116961NIGMS NIH HHS R35 GM157192
6 · The paper itself

Abstract

Nanobodies (Nbs) that depolymerize bacterial surface-layers (S-layers) offer a route to antivirulence therapeutics, but their mechanisms have been difficult to infer from binding structures alone. In

Identifiers

PMID42427516
PMCPMC13345343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.