Evidence map›Paper›PMID 42427515›Full record

ArticlebioRxiv : the preprint server for biology2026

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.

Tianli Xiao, J Richard Brewer, Maximilian Carlino, Ailin Han, Yamato Takabe, Chia-Yi Lee, Fengrui Zhang, Mi Chen, Holly Nicole Blackburn, Amin H Nassar and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Tianli XiaoDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-4508-3973
J Richard BrewerDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Maximilian CarlinoYale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1578-8024
Ailin HanDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Yamato TakabeDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Chia-Yi LeeDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Fengrui ZhangDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Mi ChenDepartment of Laboratory Medicine, Yale University, New Haven, CT, USA.
Holly Nicole BlackburnDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Amin H NassarDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Qiankun WangInstitute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China.
Kristen BrennadDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0993-5956
Liang ShanInstitute of Human Immunology, Shenzhen Medical Academy of Research and Translation, China.
Esen SefikDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Diane S KrauseHoward Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut, USA.
Richard A FlavellDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0M
Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7M
Flow cytometer for high-parameter analysesS10OD026996 · OD · YALE UNIVERSITY · PI HABERMAN, ANN M · 2019 to 2019
$596k
Investigation of Dpp9 in COVID19R21AI178249 · NIAID · YALE UNIVERSITY · PI FLAVELL, RICHARD A · 2023 to 2024
$454k
NCI NIH HHS P30 CA016359NIAID NIH HHS R21 AI178249NIDDK NIH HHS U54 DK106857NIH HHS S10 OD026996
6 · The paper itself

Abstract

Loss of function mutation in the human

Identifiers

PMID42427515
PMCPMC13345154

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.