Evidence map›Paper›PMID 42427508›Full record

ArticlebioRxiv : the preprint server for biology2026

Viral capsid delivery of cGAMP enhances STING-dependent antitumor immune response.

Paul Huang, Yeara Jo, Hannah S Martin, Rutger D Luteijn, David H Raulet, Matthew B Francis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul HuangDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-3520-0032
Yeara JoDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-1340-1968
Hannah S MartinDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Rutger D LuteijnDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-6183-4573
David H RauletDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-1257-8649
Matthew B FrancisDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0003-2837-2538

Funding

Mechanisms underlying combination therapy mobilizing NK cellsR01CA270790 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAVID H RAULET · 2022 to 2026
$2.3M
Tregulatory cell-mediated suppression of tumor elimination by NK cells and CD4 T cellsR01CA303968 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michel DuPage, DAVID H RAULET · 2025 to 2026
$1.3M
NCI NIH HHS R01 CA270790NCI NIH HHS R01 CA303968
6 · The paper itself

Abstract

Therapies to activate the STING immune response pathway represent promising potential anticancer treatments. However, the native STING activating molecule, 2',3'-cGAMP, is a poor drug candidate due to its susceptibility to nuclease degradation and its relatively poor cell uptake. In this study, we present a nanoscale delivery vehicle based on the bacteriophage MS2 virus-like particle that can both protect cGAMP and deliver it into cells to access and bind cytosolic STING. MS2-delivered cGAMP achieved greatly increased STING activation potency relative to both free cGAMP and a nuclease-resistant synthetic cGAMP analog. In an

Identifiers

PMID42427508
PMCPMC13345200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.