ArticlebioRxiv : the preprint server for biology2026
Cardiovascular Benefits of Menopause Hormone Treatment is Age-Dependent.
Cassandra D Lalisan, Connor Gavin, Bridget Litts, Jeffrey A Rein, Julia An, Min Zhong, Rajguru Boobalan, Yu Wang, Amelia Van Aelst, Sivaprakasam Chinnarasu and 4 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Cassandra D LalisanDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0009-0004-0505-2499 Connor GavinDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Bridget LittsDivision of Diabetes, Metabolism and Endocrinology, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8647-4677 Jeffrey A ReinDivision of Diabetes, Metabolism and Endocrinology, Vanderbilt University Medical Center, Nashville, TN.
Julia AnDivision of Diabetes, Metabolism and Endocrinology, Vanderbilt University Medical Center, Nashville, TN.
Min ZhongDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Rajguru BoobalanDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Yu WangDepartment of Biostatistics, Vanderbilt University, Nashville, TN.
Amelia Van AelstDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Sivaprakasam ChinnarasuDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0009-0002-1863-862X MacRae LintonDivision of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-9277-0453 John M StaffordDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0000-0001-6527-959X Lin ZhuDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.ORCID 0000-0001-8149-4273 Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Marcela Brissova · 2012 to 2026
$29.3MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MSex-Specific Risk of Metabolic and Cardiovascular DiseaseR01HL144846 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Michael Stafford · 2019 to 2026
$4.1MTherapeutic Potential of Estrogen-Regulated Metabolism and Cardiovascular RiskR01DK109102 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STAFFORD, JOHN MICHAEL · 2016 to 2024
$3.6MDoes Senescence Impair the Cardiovascular Benefits of Menopause Hormone Therapy?K01AG077038 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lin Zhu · 2022 to 2026
$601kBLRD VA I01 BX002223NHLBI NIH HHS R01 HL144846NIA NIH HHS K01 AG077038NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK109102NIDDK NIH HHS U24 DK059637
6 · The paper itselfAbstract
Background: Hormone therapy (HT) has not consistently reduced atherosclerotic cardiovascular disease (ASCVD) events in post-menopausal women, yet the underlying mechanisms remain poorly understood. Methods: Female Results: In aging mice, menopause E Conclusions: The cardiovascular effects of estrogen therapy are fundamentally age dependent. Aging shifts estrogen signaling toward hepatic oxidative stress and inflammation through increased GPER. While E
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PMID42427504
PMCPMC13345000
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