Evidence map›Paper›PMID 42427492›Full record

ArticleFrontiers in immunology2026

Antibodies against interleukin-10 receptor reduce IL-6 and TNF-α levels and increase TGF-β levels in patients with severe fever with thrombocytopenia syndrome virus and SARS-CoV-2 infection.

Su Yeon Kang, Jeong Rae Yoo, EunJin Bae, Joowan Kim, Yejin Park, Misun Kim, Miyeon Kim, Hyo-Jin Ro, Daehee Hwang, Jeong-Yeon Lee and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Su Yeon Kang *Hanyang University College of Medicine and Intercollege, Seoul, Republic of Korea.
Jeong Rae Yoo *Department of Internal Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.
EunJin Bae *Hanyang University College of Medicine and Intercollege, Seoul, Republic of Korea.
Joowan Kim *Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Yejin ParkDepartment of Biochemistry, Korea University College of Medicine, Seoul, Republic of Korea.
Misun KimDepartment of Internal Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.
Miyeon KimDepartment of Internal Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.
Hyo-Jin RoDepartment of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Daehee HwangSchool of Biological Science, Seoul National University, Seoul, Republic of Korea.
Jeong-Yeon LeeHanyang University College of Medicine and Intercollege, Seoul, Republic of Korea.
Dongcharn ChoHanyang University College of Medicine and Intercollege, Seoul, Republic of Korea.
Huy Chau NguyenUS Naval Medical Research Unit INDO PACIFIC, Singapore, Singapore.
Hoai Jaclyn HallamUS Naval Medical Research Unit INDO PACIFIC, Singapore, Singapore.
Sang Taek HeoDepartment of Internal Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.
Nam-Hyuk ChoDepartment of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kyung-Mi LeeDepartment of Biochemistry, Korea University College of Medicine, Seoul, Republic of Korea.
Andrew G LetiziaUS Naval Medical Research Unit INDO PACIFIC, Singapore, Singapore.
Keun Hwa LeeHanyang University College of Medicine and Intercollege, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause severe, often fatal, disease characterized by hyperinflammation and features of a cytokine storm. Hyperproduction of both IL-10 and IL-6 and low TGF-β production can generate a cytokine storm, with IL-10 playing a particularly important role. To investigate the role of IL-10 in patients with SFTS, we analyzed the phenotypes of macrophages, cytokines, and signaling pathways in patients with mild to fatal SFTS and found that the population of HLA-DR

Indexed as

AntibodiesCOVID-19Interleukin-6Receptors, Interleukin-10Severe Fever with Thrombocytopenia SyndromeTransforming Growth Factor betaTumor Necrosis Factor-alphaAdultAgedFemaleHumansInterleukin-10MacrophagesMaleMiddle AgedSARS-CoV-2AntibodiesIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6Receptors, Interleukin-10Smad3 ProteinSMAD3 protein, humanTransforming Growth Factor betaTumor Necrosis Factor-alphaantibodies against interleukin-10 receptorIL-6SARS-CoV-2severe fever with thrombocytopenia syndromeTGF‐βTNF-α

Identifiers

PMID42427492
PMCPMC13347219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.