Evidence map›Paper›PMID 42427483›Full record

ReviewMediastinum (Hong Kong, China)2026

Preoperative and anesthetic management of high-risk cardiovascular complications of mediastinal masses: a narrative review.

Keith Nishihara, Nikitha Reddy, Kevin S Tang

Abstract readReview
In one paragraph

Review in Mediastinum (Hong Kong, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Keith NishiharaDepartment of Medicine, University of California Irvine Medical Center, Orange, CA, USA.
Nikitha ReddyDepartment of Medicine, University of California Irvine Medical Center, Orange, CA, USA.
Kevin S TangDepartment of Medicine, University of California Irvine Medical Center, Orange, CA, USA.ORCID https://orcid.org/0000-0003-4160-1868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: The mediastinum is a complex anatomical region that includes the heart, aorta, superior vena cava, trachea, and mainstem bronchi. Mediastinal masses, while relatively uncommon, can cause life-threatening cardiovascular symptoms from mass effect, including cardiac tamponade, superior vena cava syndrome, mediastinal mass syndrome, and right ventricular outflow tract obstruction, requiring prompt identification and management. Currently, there are no guidelines that discuss the optimal management of these cardiovascular complications, and our review aims to address this. Methods: A database search in PubMed was conducted from September 2025 to November 2025, including articles related to mediastinal masses and the various cardiovascular complications that can arise. Selected articles were compiled and reviewed to help compose this review. Key Content and Findings: This review aims to outline the incidence and etiology of different mediastinal masses, review the presentation and diagnostic workup, highlight key life-threatening syndromes related to mass effect, and discuss definitive management of these lesions. Given the complexity of the mediastinum and potential for several life-threatening complications without appropriate identification, timely diagnosis is needed to guide management. Conclusions: A multidisciplinary approach is crucial in the stabilization and management of these patients with mediastinal masses and should be considered the standard of care in all patients. This review aims to summarize current literature for the management of cardiovascular complications related to mediastinal masses.

Indexed as

cardiac tamponadeMediastinal masssuperior vena cava syndrome (SVC syndrome)

Identifiers

PMID42427483
PMCPMC13346010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.