Evidence map›Paper›PMID 42427448›Full record

ArticleBio-protocol2026

An Optimized Protocol for the Characterization of Zebrafish ApoB-Containing Lipoproteins Using the LipoGlo System.

Monica R Hensley, Steven A Farber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Monica R HensleyDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Steven A FarberDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.

Funding

Systematic Vertebrate Functional GenomicsR01GM063904 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EKKER, STEPHEN CARL · 2001 to 2025
$10.7M
Identifying genes required for digestive physiology and lipid metabolismR01DK093399 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEVEN A FARBER, John F Rawls · 2013 to 2026
$7.6M
Mapping MTP lipid transfer activities for better therapeuticsR01HL158054 · NHLBI · NYU LONG ISLAND SCHOOL OF MEDICINE · PI FARBER, STEVEN A, HUSSAIN, M MAHMOOD · 2021 to 2024
$2.4M
Defining the role of PLA2G12B on apoB-containing lipoprotein assembly, plasma levels, metabolism and cardiovascular disease riskR01DK138195 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEVEN A FARBER, M Mahmood Hussain · 2025 to 2026
$1.2M
NHLBI NIH HHS R01 HL158054NIDDK NIH HHS R01 DK093399NIDDK NIH HHS R01 DK138195NIGMS NIH HHS R01 GM063904
6 · The paper itself

Abstract

Apolipoprotein B-containing lipoproteins (ApoB-LPs) transport lipids throughout the circulation and are closely associated with cardiovascular disease in humans. Many aspects of ApoB-LP biology remain elusive, often due to their indirect characterization through the measurement of plasma triglycerides and cholesterol. The conventional approach provides limited information on ApoB-LPs number and size distribution, essential features that influence cardiovascular disease risk. Additionally, drug studies have historically been limited to the use of mammalian research models, which are not suited for high-throughput experiments. Therefore, we generated a reporter system (LipoGlo) utilizing a luciferase enzyme (NanoLuc) fused to the C-terminus of the zebrafish (

Indexed as

ApoB-containing lipoproteinsCholesterolLipoGloLipoproteinsLuciferaseZebrafish

Identifiers

PMID42427448
PMCPMC13347125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.