ArticleAdvanced biomedical research2026
Investigating the Effect of Caffeine on the Effectiveness of Crocin in Improving Behavioral Symptoms and Brain Tissue Changes in the Hippocampus in the Post-Traumatic Stress Model in Rats.
Article in Advanced biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition. Although crocin has shown potential in reducing stress-related symptoms, its low bioavailability limits its effectiveness. Caffeine may enhance the bioavailability of various compounds by modulating liver enzymes. This study examined whether caffeine could improve crocin's efficacy in a rat model of PTSD. Materials and Methods: Male Wistar rats (8-10 weeks old) were divided into five groups: control, PTSD, crocin-treated, caffeine-treated, and crocin + caffeine-treated. PTSD was induced using repeated foot shocks, followed by 7 days of treatment. Behavioral assessments were performed using the elevated plus maze and shuttle box tests. Serum corticosterone levels were measured as a biochemical marker of anxiety, and histological evaluation of the hippocampus was conducted using Cresyl Violet and Golgi-Cox staining. Results: The combination treatment significantly reduced serum corticosterone levels compared to either compound alone ( Conclusions: We concluded that a combination of crocin and caffeine could improve the efficacy of crocin given alone. These findings indicate that caffeine can help further enhance the neuroprotective efficacy of crocin in this model.
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