ArticleRSC advances2026
Method development and validation for determination of entinostat in human plasma and its application in breast cancer patients.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Entinostat is an oral histone deacetylase (HDAC) inhibitor used in HR+ breast cancer therapy, for which reliable plasma concentration monitoring is essential for dose optimization and toxicity management. This article described an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the quantitative analysis of entinostat in human plasma. Samples were concentrated under vacuum after methanol precipitation and separated on a Kinetex C18 column (100 mm × 2.1 mm, 2.6 µm). The mobile phase consisted of acetonitrile and an aqueous solution containing 10 mM ammonium acetate and 0.01% formic acid. The quantitative ion pair for entinostat was
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