Evidence map›Paper›PMID 42427347›Full record

SynthesisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Triple Antithrombotic Therapy vs Dual Antiplatelet for Prevention of Left Ventricular Thrombus After Anterior Myocardial Infarction: An Updated Meta-Analysis.

Mustafa Abomohsen, Ibrahim Elkhayat, Ahmed Elmorsy Mohamed, Abdul Hakim Almakadma, Zeyad Kholeif, Ahmed Farid Gadelmawla, Ameer Awashra, Muhammed A Youssef, Osamah AlQassab, Mohamed Ghannam and 6 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mustafa AbomohsenDepartment of Internal Medicine, Brookdale University Hospital & Medical Center, Brooklyn, NY, USA.
Ibrahim ElkhayatDepartment of Cardiology, El Zaitoun Specialized Hospital, Cairo, Egypt.ORCID 0009-0001-7919-755X
Ahmed Elmorsy MohamedDepartment of Internal Medicine, Brookdale University Hospital & Medical Center, Brooklyn, NY, USA.
Abdul Hakim AlmakadmaDepartment of Internal Medicine, Brookdale University Hospital & Medical Center, Brooklyn, NY, USA.
Zeyad KholeifDepartment of Internal Medicine, Baptist Hospital of Southeast Texas, Beaumont, TX, USA.
Ahmed Farid GadelmawlaFaculty of Medicine, Menoufia University, Menoufia, Egypt.ORCID 0000-0002-5802-2291
Ameer AwashraDepartment of Internal Medicine, An-Najah University, Nablus, Palestine.ORCID 0009-0002-5122-8200
Muhammed A YoussefDepartment of Cardiology, October 6th University, Giza, Egypt.
Osamah AlQassabDepartment of Internal Medicine, Brookdale University Hospital & Medical Center, Brooklyn, NY, USA.
Mohamed GhannamDepartment of Internal Medicine, Brookdale University Hospital & Medical Center, Brooklyn, NY, USA.
Vikas PatelDepartment of Internal Medicine, Brookdale University Hospital & Medical Center, Brooklyn, NY, USA.
Azad MojahediDepartment of Internal Medicine, Brookdale University Hospital & Medical Center, Brooklyn, NY, USA.
Iyad IdriesDivision of Cardiology, One Brooklyn Health, Brooklyn, NY, USA.
Meena FaridDivision of Cardiology, One Brooklyn Health, Brooklyn, NY, USA.
Moshe GunsburgDivision of Cardiology, One Brooklyn Health, Brooklyn, NY, USA.
Hal L ChadowDivision of Cardiology, One Brooklyn Health, Brooklyn, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PurposeTo evaluate the efficacy and safety of triple antithrombotic therapy (TT) versus dual antiplatelet therapy (DAPT) for prevention of left ventricular thrombus (LVT) following anterior myocardial infarction.MethodsWe conducted a systematic review and meta-analysis of randomized and observational studies comparing TT (DAPT plus anticoagulation) versus DAPT alone. The primary outcome was LVT formation. Secondary outcomes included all-cause mortality, stroke, systemic embolism, composite thromboembolism, bleeding, and net adverse clinical events (NACE). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. The protocol was registered in PROSPERO (CRD420261343867).ResultsSeven studies (2 randomized, 5 observational), including 2,273 patients (949 TT, 1,324 DAPT), were analyzed. TT was not associated with a reduction in LVT (OR 0.56, 95% CI 0.21-1.49; p=0.25; I

Indexed as

Anterior Wall Myocardial InfarctionFibrinolytic AgentsHeart VentriclesMyocardial InfarctionPlatelet Aggregation InhibitorsThrombosisFemaleHumansMaleFibrinolytic AgentsPlatelet Aggregation Inhibitorsacute coronary syndromedual antiplatelet therapyleft ventricular thrombustriple antithrombotic therapy

Identifiers

PMID42427347
PMCPMC13354908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.