Evidence map›Paper›PMID 42427338›Full record

ArticleStroke2026

Sex Differences in Screening for Large Vessel Occlusion and Thrombectomy: A Population-Based Cohort Study.

Yasodara P S Siddharthan, Moira K Kapral, Jiming Fang, Peter C Austin, Anahita Carbonneau, Michael D Hill, Albert Jin, Jennifer Mandzia, Frank L Silver, Amy Y X Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yasodara P S SiddharthanDepartment of Medicine (Neurology), University of Toronto, Sunnybrook Health Sciences Centre, ON, Canada (Y.P.S.S., A.Y.X.Y.).ORCID 0000-0003-0660-4377
Moira K KapralDepartment of Medicine (General Internal Medicine) (M.K.K.), University of Toronto, University Health Network, ON, Canada.ORCID 0000-0002-3444-9928
Jiming FangInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada (M.K.K., J.F., P.C.A., A.C., A.Y.X.Y.).ORCID 0000-0002-4526-0987
Peter C AustinInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada (M.K.K., J.F., P.C.A., A.C., A.Y.X.Y.).ORCID 0000-0003-3337-233X
Anahita CarbonneauInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada (M.K.K., J.F., P.C.A., A.C., A.Y.X.Y.).ORCID 0009-0006-6619-3388
Michael D HillDepartment of Clinical Neurosciences, Community Health Sciences, Hotchkiss Brain Institute, University of Calgary, AB, Canada (M.D.H.).ORCID 0000-0002-6269-1543
Albert JinDepartment of Medicine (Neurology), Queen's University, Kingston Health Sciences Centre, ON, Canada (A.J.).ORCID 0000-0001-8445-1447
Jennifer MandziaDepartment of Clinical Neurosciences, Western University, London Health Sciences Centre University Hospital, ON, Canada (J.M.).ORCID 0000-0002-1331-0695
Frank L SilverDepartment of Medicine (Neurology) (F.L.S.), University of Toronto, University Health Network, ON, Canada.ORCID 0000-0002-7569-8429
Amy Y X YuDepartment of Medicine (Neurology), University of Toronto, Sunnybrook Health Sciences Centre, ON, Canada (Y.P.S.S., A.Y.X.Y.).ORCID 0000-0002-7276-9551
SMART-EVT Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPopulation-based sex differences in large vessel occlusion (LVO) screening and thrombectomy use for acute ischemic stroke are not well understood. We compared the detection of LVO, thrombectomy use, and long-term clinical outcomes in female versus male patients with cerebral ischemia in Ontario, Canada.

methodsThis retrospective cohort study used data from the Ontario Stroke Registry linked with health administrative data. We included adult patients hospitalized for cerebral ischemia within the first 24 hours of last seen normal time during 2 fiscal years (2019/2020 and 2022/2023). We used modified Poisson regression models to evaluate sex differences in intracranial neurovascular imaging, thrombolysis, or thrombectomy. Among patients with LVO, we used Cox proportional hazard and cause-specific hazard models to compare female versus male patients long-term mortality, readmission, or nursing home admission until 2025, stratified by thrombectomy treatment.

resultsAmong 16 935 eligible patients (47% female patients; median age, 76 [interquartile range, 65-84] years), female patients were less likely than male patients to receive intracranial neurovascular imaging (83.6% female versus 87.8% male;

conclusionsFemale patients with acute cerebral ischemia were less likely than male patients to receive intracranial neurovascular imaging but more likely to have an LVO, and long-term mortality was lower in female patients with LVO treated with thrombectomy. Stroke outcomes' research must account for neurovascular imaging and LVO status to accurately identify sex-based disparities in stroke care and outcomes.

Indexed as

Brain IschemiaIschemic StrokeSex CharacteristicsThrombectomyAgedAged, 80 and overCohort StudiesFemaleHumansMaleOntarioRegistriesRetrospective StudiesSex Factorsepidemiologyhealth services researchsex differencesstrokethrombectomy

Identifiers

PMID42427338
PMCPMC13506182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.