Evidence map›Paper›PMID 42427320›Full record

ArticleNeuropathology and applied neurobiology2026

Frontotemporal Lobar Degeneration-TDP Type C With Striatal Glial Cytoplasmic Inclusions and Motor Neuron Degeneration.

Akiko Uchino, Kazutomi Kanemaru, Airi Tarutani, Masato Hasegawa, Hiroya Naruse, Hiroyuki Ishiura, Shigeo Murayama, Yuko Saito

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropathology and applied neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akiko UchinoDepartment of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Kazutomi KanemaruDepartment of Neurology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Airi TarutaniDepartment of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID https://orcid.org/0000-0003-3835-9070
Masato HasegawaDepartment of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Hiroya NaruseDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroyuki IshiuraDepartment of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0003-2975-7309
Shigeo MurayamaDepartment of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9709-5242
Yuko SaitoDepartment of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.

Funding

Japan Agency for Medical Research and Development JP21wm0425019Japan Agency for Medical Research and Development JP24dk0207074h0001Japan Agency for Medical Research and Development JP25wm0625126MEXT/JSPS KAKENHI JP22H04923Research on rare and intractable diseases Program JPMH23FC1008
6 · The paper itself

Abstract

We report an autopsy case of frontotemporal lobar degeneration (FTLD)-TDP type C with severe striatal involvement and annexin A11- and phosphorylated TDP-43-positive glial cytoplasmic inclusions. The patient developed progressive asymmetric rigidity accompanied by marked striatal atrophy and showed both upper and lower motor neuron involvement. These findings expand the clinicopathological spectrum of FTLD-TDP type C and may support the concept of an annexin A11-associated pathogenic continuum linking FTLD and amyotrophic lateral sclerosis.

Indexed as

Corpus StriatumDNA-Binding ProteinsFrontotemporal Lobar DegenerationInclusion BodiesMotor Neuron DiseaseMotor NeuronsNeurogliaAgedFemaleHumansMaleDNA-Binding ProteinsTARDBP protein, humanamyotrophic lateral sclerosisannexin A11corticobasal syndromefrontotemporal lobar degenerationglial cytoplasmic inclusionsmotor neuron diseaseTDP‐43

Identifiers

PMID42427320
PMCPMC13352230

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.