Evidence map›Paper›PMID 42427267›Full record

ArticleDevelopment (Cambridge, England)2026

The cloacal outgrowth orchestrates co-development of the bladder and umbilical arteries.

Xing Ye, Liguang Xia, Xianfa Yang, Ruirong Tan, Haochuan Zhang, Liming Lei, Jungang Huang, Yingsheng Zhang, Edward Morrisey, Ping Zhu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Xing YeDepartment of Medicine, Department of Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Cedars-Sinai Health Sciences University, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Liguang XiaDepartment of Urology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA.
Xianfa YangGuangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510005, People's Republic of China.
Ruirong TanDepartment of Medicine, Department of Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Cedars-Sinai Health Sciences University, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Haochuan ZhangDepartment of Urology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA.
Liming LeiDepartment of Urology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA.
Jungang HuangDepartment of Urology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA.
Yingsheng ZhangDepartment of Medicine, Department of Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Cedars-Sinai Health Sciences University, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.ORCID 0000-0002-1580-2781
Edward MorriseyDepartment of Medicine, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ping ZhuGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510100, People's Republic of China.ORCID 0000-0002-4276-9593
Zhongrong LiDepartment of Pediatric Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, People's Republic of China.
Naihe JingGuangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510005, People's Republic of China.
Xue LiDepartment of Medicine, Department of Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Cedars-Sinai Health Sciences University, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.ORCID 0000-0002-3072-0573

Funding

The Role of the Y Chromosome in Bladder Tumor Development, Growth And ProgressionP01CA278732 · NCI · CEDARS-SINAI MEDICAL CENTER · PI Hany Abdel-Malek Abdel-Hafiz · 2023 to 2026
$10.7M
Sexual Dimorphism in Bladder CancerR01CA267108 · NCI · CEDARS-SINAI MEDICAL CENTER · PI Xue Sean Li · 2022 to 2026
$2.9M
The single and same cell 3D atlas of epigenome and transcriptome of the lower urinary tractU01DK131377 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2021 to 2025
$2.3M
The Six-Family Genes in Cardiovascular Development And DiseaseR01HL136921 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2017 to 2020
$2.3M
Molecular Basis of Sexually Dimorphic Development of the Genital TubercleR01DK110477 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2017 to 2021
$1.9M
Cedars-Sinai Medical CenterNational Heart Lung and Blood Institute 1R01HL136921NCI NIH HHS 1P01CA278732NCI NIH HHS 1R01CA267108NCI NIH HHS P01 CA278732NCI NIH HHS R01 CA267108NHLBI NIH HHS 1R01HL136921NHLBI NIH HHS R01 HL136921NIDDK NIH HHS R01 DK110477NIDDK NIH HHS R01DK110477NIDDK NIH HHS U01 DK131377NIDDK NIH HHS U01DK131377
6 · The paper itself

Abstract

The urinary bladder is an innovation of eutherian mammals to manage liquid waste. However, bladder development and its embryonic function remain poorly understood. Here, we report that in both humans and mice the bladder emerges from the cloaca as a rostral outgrowth, which is flanked by the umbilical arteries. Arrest of the outgrowth, as seen in Shh-null mouse embryos, causes bladder agenesis and unexpected severe defects of the umbilical arteries, suggesting that the outgrowth epithelial signal Shh coordinates development of both the bladder and the umbilical arteries. The signaling molecule Wnt2 is restricted to the rostral outgrowth mesenchyme and its expression is dramatically downregulated in Shh-null mutants. Furthermore, Wnt2-null mutants develop a small bladder and single umbilical artery defects. Collectively, we uncover an unexpected co-development mechanism of the bladder and umbilical arteries orchestrated by the cloacal outgrowth signals. The co-development paradigm offers a conceptual framework to understand evolution and development of the bladder.

Indexed as

CloacaUmbilical ArteriesUrinary BladderAnimalsGene Expression Regulation, DevelopmentalHedgehog ProteinsHumansMiceSignal TransductionWnt2 ProteinHedgehog ProteinsShh protein, mouseWnt2 ProteinAllantoisBladderCloacaGeo-seqHigh resolution episcopic microscope (HREM)ShhUmbilical arteryWnt2

Identifiers

PMID42427267
PMCPMC13480954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.