Evidence map›Paper›PMID 42427244›Full record

ArticleChemistry & biodiversity2026

In Vivo Anti-Nociceptive Activity of Isoquercetin in Rats Supported by ADMET and Molecular Docking Analysis.

Ridha Ben Ali, Dorra Ben Said, Mariam Bourounia, Jalloul Bouajila, Abada Mhamdi, Sihem El Aidli

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ridha Ben AliUnit of Experimental Medicine, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Dorra Ben SaidDepartement of Pharmacology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Mariam BourouniaDepartement of Pharmacology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Jalloul BouajilaLaboratoire De Génie Chimique, Université De Toulouse, Toulouse, France.ORCID https://orcid.org/0000-0002-2439-5145
Abada MhamdiLaboratoiry of Research LR24ES10, Santé Populationnelle, Agresseurs Environnementaux, Thérapies alternatives, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-9329-046X
Sihem El AidliDepartement of Pharmacology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to evaluate the anti-nociceptive activity of isoquercetin (IQN) in rats and to determine its mechanism of action using molecular docking. The preliminary study was conducted to determine physicochemical and pharmacological parameters of IQN, an in vitro method was used to assess its antioxidant capacity. Behavioral tests were carried out to evaluate its anti-nociceptive activity and an in silico molecular docking study was performed to understand the molecule's mechanism of action. The preliminary study demonstrated that IQN is nontoxic to metabolism and organs, with an LD

Indexed as

AnalgesicsAntioxidantsMolecular Docking SimulationQuercetinAnimalsCyclooxygenase 2Dose-Response Relationship, DrugMaleMolecular StructureRatsRats, WistarStructure-Activity RelationshipAnalgesicsAntioxidantsCyclooxygenase 2QuercetinADMET analysisanti‐inflammatoryanti‐nociceptiveantioxidantisoquercetinmolecular docking

Identifiers

PMID42427244
PMCPMC13352103

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.