ArticleCancer medicine2026
Community Experience With Pediatric-Inspired Regimens for Acute Lymphoblastic Leukemia in Adolescent and Young Adults.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) are a growing population with unfavorable outcomes relative to pediatric peers. Historic underrepresentation in prospective studies has complicated unifying recommendations surrounding optimal therapeutic strategy for this group. Retrospective studies highlighting the superiority of pediatric-inspired regimens in this context have given rise to small prospective trials supporting these findings. Data demonstrating concordant implementation of these protocols outside of clinical trials is lacking. We designed a retrospective study summarizing therapeutic strategies for over 200 AYAs with ALL treated within an integrated healthcare system. We found increasing usage of pediatric protocols over the study period associated with higher utilization of outpatient clinic appointments, lower number of inpatient days, equivalent toxicity profiles, and favorable mortality rates. Our findings highlight the wide implementation and superiority of pediatric regimens for AYAs undergoing treatment for ALL in the community setting, for which more data have been needed.
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