Evidence map›Paper›PMID 42427029›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Rescue of stereocilia architecture and hearing function by AAV-CIB2 and AAV-CIB3 in a mouse model of recessive deafness DFNB48.

Sakina Rehman, Arnaud P J Giese, Abigail K Dragich, Saima Riazuddin, Gregory I Frolenkov, Zubair M Ahmed

Abstract read
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In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sakina RehmanLaboratory of Neurogenetics and Translational Research, Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore 54500, Pakistan.
Arnaud P J GieseLaboratory of Neurogenetics and Translational Research, Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Abigail K DragichDepartment of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Saima RiazuddinLaboratory of Molecular Genetics, Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Molecular Biology and Biochemistry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Gregory I FrolenkovDepartment of Physiology, University of Kentucky, Lexington, KY 40536, USA; Department of Otolaryngology - Head & Neck Surgery, University of Kentucky, Lexington, KY 40536, USA.
Zubair M AhmedLaboratory of Neurogenetics and Translational Research, Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Molecular Biology and Biochemistry, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: zmahmed@som.umaryland.edu.

Funding

Usher Proteins in the Inner Ear Structure and FunctionR01DC012564 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI Zubair M. Ahmed, Gregory I Frolenkov · 2013 to 2026
$7.0M
NIDCD NIH HHS R01 DC012564
6 · The paper itself

Abstract

Pathogenic variants in the calcium and integrin-binding protein 2 (CIB2) are among the leading causes of nonsyndromic prelingual hearing loss (DFNB48). Loss of Cib2 in mice causes severe stereocilia bundle defects, impaired mechanoelectrical transduction (MET), and profound hearing loss. To determine whether a critical window of opportunity exists to restore the stereocilia architecture and to rescue hearing function, we developed and investigated the effect of adeno-associated virus (AAV)-mediated gene delivery in Cib2 mutant mice. A single administration of the AAV-Cib2 vector was performed via semicircular canal injections in Cib2

Indexed as

Calcium-Binding ProteinsDeafnessDependovirusGenetic VectorsHearingStereociliaAnimalsAuditory AcuityDisease Models, AnimalGene Therapy AgentsGenetic TherapyHumansMiceMice, KnockoutCalcium-Binding ProteinsAAVauditory hair cellsCIB2CIB3deafnessDFNB48gene therapyhearing lossmechanotransductionstereocilia

Identifiers

PMID42427029
PMCPMC13455004

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.