Evidence map›Paper›PMID 42427022›Full record

ReviewJournal of genetics2026

Lyonization of X-chromosome: New insights.

H A Ranganath

Abstract readReview
PubMed
In one paragraph

Review in Journal of genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

H A RanganathCentre for Human Genetics, Biotech Park, Electronic City Phase 1, Bangalore 560 100, India.haranganath@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ever since Mary Lyon (Nature 190:372-373, 1961) proposed the phenomena of X-chromosome inactivation (XCI) in female mammals, our quest to understand the mechanism underlying it is in progress. Our current knowledge of X-chromosome inactivation (XCI) is due to the application of state-of-the-art genomic and transcriptomic technologies, advanced microscopy, and cutting-edge in vitro differentiation models. The role of long-noncoding RNA Xist along with proteins (ribonucleoproteins) in the epigenetic silencing has led to the better understanding of XCI. Now attempts are on the way to reverse X-chromosome repression at specific gene loci in the female genome and to cure X-linked disease. This review presents narrative includes a comprehensive overview of these developments.

Indexed as

X ChromosomeX Chromosome InactivationAnimalsEpigenesis, GeneticFemaleHumansRNA, Long NoncodingRNA, Long NoncodingXIST non-coding RNA

Identifiers

PMID42427022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.