Evidence map›Paper›PMID 42426985›Full record

ArticleJournal of medical primatology2026

The Potency of Extracellular Vesicles Derived From Mesenchymal Stem Cells Macaca fascicularis as a Candidate Cancer Therapeutic Agents.

Silmi Mariya, Wahono Esthi Prasetyaningtyas, Ni Luh Putu Ika Mayasari, Iin Indriawati, Hepy Dayana, Uus Saepuloh, Huda Shalahudin Darusman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Silmi MariyaPrimate Research Center, IPB University, Bogor, Indonesia.ORCID https://orcid.org/0000-0002-6714-1276
Wahono Esthi PrasetyaningtyasSchool of Veterinary Medicine and Biomedical Science, IPB University, Bogor, Indonesia.
Ni Luh Putu Ika MayasariSchool of Veterinary Medicine and Biomedical Science, IPB University, Bogor, Indonesia.
Iin IndriawatiPrimate Research Center, IPB University, Bogor, Indonesia.
Hepy DayanaPrimate Research Center, IPB University, Bogor, Indonesia.
Uus SaepulohPrimate Research Center, IPB University, Bogor, Indonesia.
Huda Shalahudin DarusmanPrimate Research Center, IPB University, Bogor, Indonesia.

Funding

Fundamental Research-National Competitive Research Regular 22042/IT3.D10/PT.01.03/P/B/2024
6 · The paper itself

Abstract

backgroundExtracellular vesicles (EVs) are membrane vesicles secreted by cells that carry several bioactive molecules, which are currently used in biomedical research as a source of exosomes and to investigate their effect in response to cancer studies.

methodsEVs isolated from the supernatant of Macaca fascicularis Mesenchymal Stem Cells (MSCs), using the commercial ExoQUICK kit, and markers validation evaluated using quantitative reverse transcription Polymerase Chain Reaction (qRT-PCR). EVs were further applied on breast cancer cells (MCF-7) and colorectal cancer cells (WiDr).

resultsThe application of EVs to MCF-7 and WiDr cells showed growth inhibition and resulted in the cells' viability decreased compared to untreated cells. The apoptosis (BAX and BCL2) and proliferation markers (PCNA and P53) on both cells demonstrated increasing than untreated cells, expecting that the EVs prevent the cells' growth uncontrolled.

conclusionThe EVs have the potential to inhibit the growth of cancer and colon cancer in vitro, determining their potential for developing as an anticancer agent.

Indexed as

Antineoplastic AgentsExtracellular VesiclesMacaca fascicularisMesenchymal Stem CellsAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalFemaleHumansAntineoplastic Agentsapoptosisexosomeextracellular vesicleMCF‐7WiDr

Identifiers

PMID42426985
PMCPMC13351192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.