ArticleActa physiologica (Oxford, England)2026
Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion.
Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology. To address these limitations, we developed a novel chronic HLI model using an ilio-femoral endovascular catheter occlusion (IFCO) approach. We hypothesized that IFCO would chronically reduce hindlimb blood flow, induce PAD-associated myopathy, and overcome limitations of conventional techniques. Laser Doppler perfusion imaging demonstrated that IFCO reduced resting hindlimb perfusion by 70%, with significant reductions persisting for up to 28 days. Histological analysis of the soleus revealed significantly increased fibrosis (4.99% in sham vs. 13.19% in IFCO) and reduced myofiber cross-sectional area (3072.21 μm
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