ArticleBehavioral and brain functions : BBF2026
Microglia-specific NLRP3 inhibition mitigates hippocampal neuroinflammation and cognitive deficits after hemorrhagic shock with resuscitation.
Article in Behavioral and brain functions : BBF, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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12 authors.
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Abstract
backgroundCognitive dysfunction is a prevalent mental health problem following hemorrhagic shock with resuscitation (HSR). Our previous work indicated that neuroinflammation caused by nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), which is modulated by glial cells, such as microglia, is potentially significant in developing emotional and cognitive dysfunction. However, little is known about the potential of microglial NLRP3 to treat HSR-induced cognitive dysfunction. Therefore, this study established an HSR rodent model to investigate whether microglial NLRP3 represents a potential therapeutic target for improving cognitive dysfunction after HSR.
methodsAn HSR model was developed by inducing bleeding and retransfusion in mice. The Morris water maze and Novel object recognition tests were used for behavioral evaluation. To selectively knock out the NLRP3 inflammasome in microglia, the AAV‑CX3CR1‑Cre (pAAV‑CX3CR1‑NLS‑Cre‑P2A‑EGFP‑3xFLAG‑WPRE) virus was stereotaxically injected into the hippocampal CA1 region of male C57BL/6 mice with NLRP3
resultsOur findings indicated that the NLRP3 inhibitor MCC950 significantly reversed HSR-induced lower recognition index, increased escape latency, reduced platform crossings, decreased θ and γ power and θ-γ phase coupling, decreased intensity of PSD95 and Synaptophysin, increased number of Iba1
conclusionOur study demonstrates that inhibition of microglia‑specific NLRP3 can mitigate cognitive impairment following HSR, identifying microglial NLRP3 as a promising therapeutic target. This effect may be associated with suppressing pyroptosis via the NLRP3 signaling pathway in microglia.
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